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Last updated on April 21, 2014 at 9:29 EDT

Latest Genome-wide association study Stories

2010-04-12 15:03:07

A large genetic study of age-related macular degeneration (AMD) has identified three new genes associated with this blinding eye disease"”two involved in the cholesterol pathway. Results of this large-scale collaborative study, supported by the National Eye Institute (NEI), part of the National Institutes of Health, were published online April 12 in the Proceedings of the National Academy of Sciences. "Genome-wide association studies require large numbers of patients to discover...

2010-03-25 12:41:56

A variation at the location of the GPC5 gene appears to reduce risk of the heart disorder that claims more than 250,000 American lives each year Physician-scientists at the Cedars-Sinai Heart Institute have found that a genetic variation is associated with lower risk of sudden cardiac arrest, a disorder that gives little warning and is fatal in about 95 percent of cases. Findings are published in the March 25 issues of PloS One. The discovery came from a genome-wide association study, which...

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2010-03-18 09:35:34

In the ongoing quest to identify the genetic factors involved in disease, scientists have increasingly turned to genome-wide association studies, or GWAS, which enable the scanning of up to a million genetic markers in thousands of individuals. These studies generally compare the frequency of genetic variants between two groups "” those with a particular disease and healthy individuals. Differences in the frequency of a given variant suggest the variant may be involved in the disease....

2010-03-01 15:46:48

Alcohol dependence (AD) is a complex disease for which both genetic and environmental factors affect susceptibility. Previous research had identified several genes associated with AD through linkage analysis or candidate-gene approaches. Findings from a genome-wide association study (GWAS) support an association between AD and a cluster of genes on chromosome 11. Results will be published in the May 2010 issue of Alcoholism: Clinical & Experimental Research and are currently available at...

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2010-02-26 08:50:00

Several genes affect tooth development in the first year of life, according to the findings of a study conducted at Imperial College London, the University of Bristol in the UK and the University of Oulu in Finland. The research, published February 26 in the open-access journal PLoS Genetics, shows that the teeth of babies with certain genetic variants tend to appear later and that these children have a lower number of teeth by age one. Additionally, those children whose teeth develop later...

2010-02-21 13:15:12

Gene associated with atrial fibrillation in younger patients without known risk factors An international research team has identified a common gene variant associated with a form of the irregular heartbeat called atrial fibrillation. In their report in the journal Nature Genetics, being published online, the investigators describe finding that variations affecting a protein that may help control the heart's electrical activity appear to increase the risk of what is called lone atrial...

2010-01-26 13:26:17

Researchers challenge prevailing assumptions in interpreting genome-wide studies In the decade since the Human Genome Project produced the first map of DNA sequences in the human genome, scientists throughout the world have combed through genome data to identify genes and gene variants that cause human disease. A new study suggests that researchers may need to broaden their search farther afield to pinpoint rare but powerful disease-causing mutations. Researchers from two large genome...

2010-01-26 12:29:37

Scientists at Duke University Medical Center say they are now convinced that rare genetic variants "“ as opposed to more common ones "“ lie at the heart of the genetic component of most common diseases. The finding appearing in PLoS Biology, stems from a series of simulation studies, and challenges common interpretations of a multitude of genome-wide association studies (GWAS) that have identified thousands of single-DNA letter changes associated with greater risk of common...

2009-12-17 13:08:31

Largest genome-wide association study of an infectious disease In the first genome-wide association study (GWAS) of leprosy and the largest GWAS on an infectious disease, scientists at the Genome Institute of Singapore (GIS) and 26 institutes in China identified seven genes that increase an individual's susceptibility to leprosy. The discovery of these genes, reported in the 16 Dec. 2009 New England Journal of Medicine, highlights the important role of the innate immune response in the...

2009-12-04 10:04:05

By measuring the total gene activity in organs relevant for coronary artery disease (CAD), scientists at the Swedish medical university Karolinska Institutet have identified a module of genes that is important for the recruitment of white blood cells into the atherosclerotic plaque. The findings, which are to be published in the open-access journal PLoS Genetics, suggest that targeting the migration of white blood cells in the development of atherosclerosis may help to reduce the risk for...