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Latest Genome-wide association study Stories

2010-06-16 23:17:59

Rare gene variants up to nine times more common in affected individuals A multi-institutional research team has found that rare variants in the gene coding an enzyme that controls the activity of a key immune cell occur more frequently in individuals with autoimmune disorders like rheumatoid arthritis and type 1 diabetes. Their report, which will appear in the journal Nature and is receiving early online release, identifies a pathway that could be a therapeutic target and may present a model...

2010-06-15 14:29:25

By investigating the association between genetic loci related to Alzheimer's disease and neuroimaging measures related to disease risk, researchers may have uncovered additional evidence that several previously studied genetic variants are associated with the development and progression of Alzheimer's disease and also may have identified new genetic risk factors for further study, according to a report in the June issue of Archives of Neurology, one of the JAMA/Archives journals. "The...

2010-06-14 14:08:25

May spare side effects to those in whom treatment would be ineffective A small genetic change can predict how people infected with hepatitis C react to treatment, paving the way to personalized therapy for this difficult to treat disease, the annual conference of the European Society of Human Genetics will hear today (Sunday 13 June). Dr. Zoltan Kutalik, from the Department of Medical Genetics, University of Lausanne, Switzerland, will tell delegates that individuals with this change, in a...

2010-05-31 13:06:10

Genome Institute of Singapore and Sun Yat-Sen University Cancer Centre identify 3 new susceptibility genes in genome-wide association study of nasopharyngeal carcinoma Scientists from Singapore, China and USA have identified three new susceptibility genes in a genome-wide association study of nasopharyngeal carcinoma (NPC). The study, led by the Genome Institute of Singapore (GIS), a biomedical research institute of the Agency for Science, Technology and Research (A*STAR), and the Sun Yat-Sen...

2010-05-27 13:34:46

While genome-wide association (GWA) studies have identified several genetic risk factors for common cancers, their predictive power is limited by their small effect sizes, according to a new study published online May 26 in the Journal of the National Cancer Institute. In the past few years, several GWA studies have reported a large number of gene-disease associations with diverse cancers. But there is ongoing debate on the robustness of these studies and the expensive technology used to...

2010-05-12 08:04:45

Although genome-wide analysis identified two genetic variations associated with Alzheimer disease (AD), these variations did not improve the ability to predict the risk of AD, according to a study in the May 12 issue of JAMA. "One of every 5 persons aged 65 years is predicted to develop AD in their lifetime, and genetic variants may play an important part in the development of the disease. The apparent substantial heritability of late-onset AD is inadequately explained by genetic variation...

2010-04-29 14:39:00

-- New Approach Also Specifies Results for Individual Patients -- PHILADELPHIA, April 29 /PRNewswire-USNewswire/ -- In findings that may speed the search for disease-causing genes, a new study challenges the prevailing view that common diseases are usually caused by common gene variants (mutations). Instead, say genetics researchers, the culprits may be numerous rare variants, located in DNA sequences farther away from the original "hot spots" than scientists have been accustomed to look....

2010-04-12 15:03:07

A large genetic study of age-related macular degeneration (AMD) has identified three new genes associated with this blinding eye disease"”two involved in the cholesterol pathway. Results of this large-scale collaborative study, supported by the National Eye Institute (NEI), part of the National Institutes of Health, were published online April 12 in the Proceedings of the National Academy of Sciences. "Genome-wide association studies require large numbers of patients to discover...

2010-03-25 12:41:56

A variation at the location of the GPC5 gene appears to reduce risk of the heart disorder that claims more than 250,000 American lives each year Physician-scientists at the Cedars-Sinai Heart Institute have found that a genetic variation is associated with lower risk of sudden cardiac arrest, a disorder that gives little warning and is fatal in about 95 percent of cases. Findings are published in the March 25 issues of PloS One. The discovery came from a genome-wide association study, which...

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2010-03-18 09:35:34

In the ongoing quest to identify the genetic factors involved in disease, scientists have increasingly turned to genome-wide association studies, or GWAS, which enable the scanning of up to a million genetic markers in thousands of individuals. These studies generally compare the frequency of genetic variants between two groups "” those with a particular disease and healthy individuals. Differences in the frequency of a given variant suggest the variant may be involved in the disease....


Word of the Day
bellycheer
  • Good cheer; viands.
  • To revel; to feast.
The word 'bellycheer' may come from 'belle cheer', "good cheer".
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