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Latest Genome-wide association study Stories

2010-02-21 13:15:12

Gene associated with atrial fibrillation in younger patients without known risk factors An international research team has identified a common gene variant associated with a form of the irregular heartbeat called atrial fibrillation. In their report in the journal Nature Genetics, being published online, the investigators describe finding that variations affecting a protein that may help control the heart's electrical activity appear to increase the risk of what is called lone atrial...

2010-01-26 13:26:17

Researchers challenge prevailing assumptions in interpreting genome-wide studies In the decade since the Human Genome Project produced the first map of DNA sequences in the human genome, scientists throughout the world have combed through genome data to identify genes and gene variants that cause human disease. A new study suggests that researchers may need to broaden their search farther afield to pinpoint rare but powerful disease-causing mutations. Researchers from two large genome...

2010-01-26 12:29:37

Scientists at Duke University Medical Center say they are now convinced that rare genetic variants "“ as opposed to more common ones "“ lie at the heart of the genetic component of most common diseases. The finding appearing in PLoS Biology, stems from a series of simulation studies, and challenges common interpretations of a multitude of genome-wide association studies (GWAS) that have identified thousands of single-DNA letter changes associated with greater risk of common...

2009-12-17 13:08:31

Largest genome-wide association study of an infectious disease In the first genome-wide association study (GWAS) of leprosy and the largest GWAS on an infectious disease, scientists at the Genome Institute of Singapore (GIS) and 26 institutes in China identified seven genes that increase an individual's susceptibility to leprosy. The discovery of these genes, reported in the 16 Dec. 2009 New England Journal of Medicine, highlights the important role of the innate immune response in the...

2009-12-04 10:04:05

By measuring the total gene activity in organs relevant for coronary artery disease (CAD), scientists at the Swedish medical university Karolinska Institutet have identified a module of genes that is important for the recruitment of white blood cells into the atherosclerotic plaque. The findings, which are to be published in the open-access journal PLoS Genetics, suggest that targeting the migration of white blood cells in the development of atherosclerosis may help to reduce the risk for...

2009-11-25 14:54:59

Genome Institute of Singapore researchers compiled map based on genome-wide variations of 6,000 samples The first genetic historical map of the Han Chinese, the largest ethnic population in the world, as they migrated from south to north over evolutionary time. was published online today by the American Journal of Human Genetics by scientists at the Genome Institute of Singapore (GIS). Based on genome-wide DNA variation information in over 6,000 Han Chinese samples from 10 provinces in China,...

2009-11-24 15:52:43

Typically conducted in richer, developed countries but now increasingly done in the developing world, genome wide association (GWA) studies raise a host of ethical issues that must be addressed, argues a Policy Forum article published this week in PLoS Medicine. Among the most pressing ethical issues is the release of data, says Michael Parker of the University of Oxford and his colleagues, who highlight the importance of developing policies and procedures for data release appropriate to GWA...

2009-10-13 10:05:00

MOUNTAIN VIEW, Calif., Oct. 13 /PRNewswire/ -- 23andMe, Inc., an industry leader in personal genetics, conducted the genetic analysis of both former and current NFL players, as well as scientific controls, to investigate how genes impact athletic performance. Over 100 players were recruited for the study, the largest genetic examination ever conducted on professional American athletes. It was performed as a result of discussions with senior writer Shaun Assael of ESPN The Magazine and...

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2009-10-12 07:42:37

Genome-wide meta-analysis identifies 22 regions associated with blood cell traits A new genome-wide association study published Oct. 11 in Nature Genetics begins to uncover the basis of genetic variations in eight blood measurements and the impact those variants can have on common human diseases. Blood measurements, including the number and volume of cells in the blood, are routinely used to diagnose a wide range of disorders, including anemia, infection and blood cell cancers. An...

2009-10-09 13:20:50

Applied to type 1 diabetes, widens net while increasing accuracy of individual risk assessments A sophisticated computational algorithm, applied to a large set of gene markers, has achieved greater accuracy than conventional methods in assessing individual risk for type 1 diabetes. A research team led by Hakon Hakonarson, M.D., Ph.D., director of the Center for Applied Genomics at The Children's Hospital of Philadelphia, suggests that their technique, applied to appropriate complex multigenic...


Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.