Latest glioblastoma multiforme Stories
Glioblastoma multiforme (GBM) is the most common malignant brain cancer in humans. Patients with GBM have a poor prognosis because it is a highly aggressive form of cancer that is commonly resistant to current therapies. A team of researchers -- led by Bo Hu and Shi-Yuan Cheng, at the University of Pittsburgh Cancer Institute, Pittsburgh -- has now identified a molecular pathway that drives the aggressive cancerous nature of a substantial proportion of glioblastomas; specifically, those that...
CLEVELAND and GAITHERSBURG, Md., Nov. 14, 2011 /PRNewswire/ -- University Hospitals (UH) Case Medical Center, Case Western Reserve University School of Medicine and Lentigen Corporation announced today the initiation of a novel Phase I clinical trial of LG631 gene therapy for the protection of hematopoietic stem cells (HSCs) from the dose limiting toxicity of chemotherapy with Temodar. Approximately 17,000 Americans are diagnosed with glioblastoma every year and only two percent of them...
SAN FRANCISCO, Nov. 14, 2011 /PRNewswire/ -- CureFAKtor Pharmaceuticals, LLC, a privately-held biopharmaceutical company focused on the research and development of Focal Adhesion Kinase (FAK) inhibitors for cancer, today presented preclinical research results at the 2011 AACR-EORTC-NCI Molecular Targets and Cancer Therapeutics Conference in San Francisco, California demonstrating that novel FAK inhibitor CFAK-Y15 decreased glioblastoma brain tumor growth in vivo and increased cell death in...
Previously unknown role of FoxM1 is crucial to regulation of brain tumor stem cells Two previously unassociated proteins known to be overly active in a variety of cancers bind together to ignite and sustain malignant brain tumors, a research team led by scientists at The University of Texas MD Anderson Cancer Center reports this week in the journal Cancer Cell. This research is the first to connect FoxM1 to a molecular signaling cascade that regulates normal neural stem cells, said...
A biotechnical company called Biomar Microbial Technologies, has recently announced its strategy to achieve an annual growth superior to 20%, from 2011 to 2014, based on the intensive internationalization and diversification policy of its Business Units in various business sectors. In like manner, Biomar has just made public the positive results it has obtained from the research carried out on some of their marine compounds to treat Glioblastoma, the most aggressive type of cancer, as well...
MUMBAI, India, October 11, 2011 /PRNewswire/ -- SIRO Clinpharm a Clinical Research Organization (CRO) with presence in Asia, Europe and U.S. highlights its successful collaboration with Peregrine Pharmaceuticals, Inc. a clinical-stage biopharmaceutical company developing first-in-class monoclonal antibodies for the treatment of cancer and viral infections. SIRO has been associated with Peregrine for the past several years and has completed a Phase II trial in India...
Researchers with UCLA's Jonsson Comprehensive Cancer Center have developed and used a high-throughput molecular screening approach that identifies and characterizes chemical compounds that can target the stem cells that are responsible for creating deadly brain tumors. Glioblastoma is one of the deadliest malignancies, typically killing patients within 12 to 18 months. These brain cancers consist of two kinds of cells, a larger, heterogeneous population of tumor cells and a smaller...
BETHESDA, Md., Oct. 6, 2011 /PRNewswire/ -- Northwest Biotherapeutics (OTC.BB: NWBO) (NORTHWEST BIO) today announced that it has exceeded its Q3 projection of 15 clinical trial sites by the end of the quarter, with 17 sites at major medical institutions across the U.S. now open and active where patients can enroll in the Company's ongoing clinical trial of DCVax® immune therapy for Glioblastoma multiforme (GBM), the most lethal form of brain cancer. The Company likewise exceeded its Q2...
PORTSMOUTH, N.H., Oct. 5, 2011 /PRNewswire/ -- Novocure, a commercial stage private oncology company, announced today that Gabriel Leung has joined its board of directors. Mr. Leung will serve as vice chairman of the board of directors and chairman of the company's global commercialization team. Mr. Leung retired as executive vice president of OSI Pharmaceuticals and the President of OSI's Pharmaceuticals Business following the Astellas Pharma Inc. acquisition of OSI in 2010. Mr. Leung...
Sanford-Burnham and Salk Institute scientists combine tumor-targeting peptides and nanoparticles to eliminate glioblastoma in a previously untreatable mouse model Glioblastoma is one of the most aggressive forms of brain cancer. Rather than presenting as a well-defined tumor, glioblastoma will often infiltrate the surrounding brain tissue, making it extremely difficult to treat surgically or with chemotherapy or radiation. Likewise, several mouse models of glioblastoma have proven...
