Latest Glioma Stories

Previously unknown role of FoxM1 is crucial to regulation of brain tumor stem cells Two previously unassociated proteins known to be overly active in a variety of cancers bind together to ignite and sustain malignant brain tumors, a research team led by scientists at The University of Texas MD Anderson Cancer Center reports this week in the journal Cancer Cell. This research is the first to connect FoxM1 to a molecular signaling cascade that regulates normal neural stem cells, said...

Scientists of the German Cancer Research Center (DKFZ) and Heidelberg University Hospital have discovered a new metabolic pathway / Successful research alliance publishes results in Nature A research alliance of Heidelberg University Hospital and the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), jointly with colleagues of the Helmholtz Center for Environmental Research in Leipzig, have discovered a new metabolic pathway which makes malignant brain tumors (gliomas)...

Brain tumor specimens taken from neurosurgery cases at the University of California, San Francisco (UCSF) Medical Center has given scientists a new window on the transformation that occurs as healthy brain cells begin to form tumors. The work may help identify new drugs to target oligodendroglioma, a common type of brain tumor, at its earliest stage, when it is generally most treatable. Any potential drugs identified will have to prove safe and effective in clinical trials, a process that...

Medulloblastomas are the most common cancerous (malignant) brain tumors in children. Although survival rates have improved over the years, medulloblastoma remains associated with substantial mortality, and long-term survivors often suffer debilitating effects from the intensive treatments. A team of researchers, led by Cecilia Söderberg-Nauclér and John Inge Johnsen, at the Karolinska Institutet, Sweden, has now identified a potential target for a more cancer-specific approach to treating...

New treatment approaches use the DCVax tumor vaccine and C-14 labeled Temozolomide to improve outcomes in brain cancer SEATTLE, Sept. 21, 2011 /PRNewswire-USNewswire/ -- The Swedish Neuroscience Institute today announced that the Ivy Brain Tumor Center has launched two separate clinical trials for treating brain cancer. The first trial (IND No. 10206, Protocol No. 020221, Study Agent: DCVax Brain - Autologous Dendritic cells and GBM tumor lysate) sponsored by Northwest Biotherapeutics,...

(Ivanhoe Newswire) – Glioblastoma is the most common brain malignancy and one of the most lethal of all cancers, killing most victims within 12-15 months of diagnosis. It is also one of the most chemotherapy-radiation resistant cancers. Researchers found that by blocking brain cancer cells from getting large amounts of cholesterol they could provide a new strategy to battle glioblastoma, according to this study. The study, done in cells lines, mouse models and analysis of tissue from...

Study led by St. Jude Children’s Research Hospital scientists points to possible new treatment targets for diffuse intrinsic pontine gliomas; may tip the scales in the current debate about tumor biopsies The largest study ever of a rare childhood brain tumor found more than half the tumors carried extra copies of specific genes linked to cancer growth, according to research led by St. Jude Children's Research Hospital investigators. The findings identify possible new targets for...

Study led by St. Jude Children's Research Hospital scientists points to possible new treatment targets for diffuse intrinsic pontine gliomas; may tip the scales in the current debate about tumor biopsies MEMPHIS, Tenn., Sept. 19, 2011 /PRNewswire-USNewswire/ -- The largest study ever of a rare childhood brain tumor found more than half the tumors carried extra copies of specific genes linked to cancer growth, according to research led by St. Jude Children's Research Hospital investigators....

Research led by St. Jude Children's Research Hospital investigators used a pioneering approach to drug development and identified dozens of potential new treatments of ependymoma, a rare tumor of the brain and spinal cord Researchers have identified promising new therapies for ependymoma, a rare tumor with few treatment options. St. Jude Children's Research Hospital investigators led the effort, which used a new, faster drug development system that combines the latest drug screening...

Glioblastoma is among the most lethal cancers, but scientists have uncovered a novel growth mechanism that suggests patients with glioblastoma could be treated with cholesterol-lowering agents, according to a study published in Cancer Discovery, the newest journal of the American Association for Cancer Research. Lead researcher Paul Mischel, M.D., Lya and Harrison Latta professor of pathology and laboratory medicine, and professor of molecular and medical pharmacology at the David Geffen...