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Latest Glucocorticoid remediable aldosteronism Stories

Sodium Retention And Blood Pressure Increased By Common Genetic Mutation
2012-05-30 08:43:57

Nearly 40 percent of the small adrenal tumors that cause big problems with high blood pressure share a genetic mutation that causes patients to retain too much sodium, researchers report. The study of 47 human, benign adrenal gland tumors also showed a mutation of the gene KCNJ5 is twice as likely to occur in women — 71 versus 29 percent — as it points to potential new treatments for some patients who don't respond to current hypertension regimens, said Dr. William E. Rainey,...

2011-02-18 08:11:45

(Ivanhoe Newswire) "“ Yale University researchers have identified two breakthrough genetic mutations that can trigger hypertension in up to a third of patients suffering from a common cause of severe high blood pressure. The findings are a major step in understanding the causes of high blood pressure, which affects one out of every three Americans, explained Richard Lifton, Sterling Professor and chair of the Department of Genetics, professor of internal medicine and senior author of...

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2011-02-11 10:25:00

High blood pressure may in some cases be caused by benign hormone-producing tumors of the adrenal cortex. A joint Swedish-American research effort has now uncovered a genetic cause behind the occurrence of such tumors. The findings were published Feb. 10 in the journal Science. Approximately 5 percent of patients with elevated blood pressure have benign endocrine tumors in their adrenal gland. The tumors produce abnormally high levels of the hormone aldosterone (the condition is known as...

2010-11-10 01:04:00

A hormone already responsible for increasing blood pressure by prompting the kidneys to retain salt appears to moonlight as a major stimulator of the brain centers that control the vascular system and blood pressure. Researchers at UT Southwestern Medical Center studied patients who overproduce aldosterone to see whether the hormone had any effect on sympathetic nerve activity responsible for blood pressure increases. "Between 10 percent and 20 percent of patients with high blood pressure who...

2009-06-04 22:18:50

Despite having normal blood pressure, U.S. researchers say overweight male teens show signs of heart damage. Researchers at the Medical College of Georgia in Augusta looked at 126 healthy 15- to 17-year-old students in a local high school and found overweight males showed elevated levels of the hormone aldosterone. This hormone produced by the adrenal gland is known to increase sodium, water retention and blood pressure. The researchers suggest the overweight males' thickened heart walls...

2009-06-01 10:52:43

Even while their blood pressures are still normal, overweight male teens may have elevated levels of a hormone known to increase pressures as well as early signs of heart damage, researchers say. Medical College of Georgia researchers looking at 126 healthy 15- to17-year-olds in high school in Augusta, Ga., found the hormone aldosterone highest among the overweight males. Early intervention could help these young people avoid growing up to be adults with cardiovascular disease, the number...

2009-03-17 11:11:23

A novel signaling pathway plays a significant role in the production of aldosterone, a hormone that promotes heart failure after a myocardial infarction, according to a study conducted by Thomas Jefferson University researchers.The findings, which will be published online this week in Proceedings of the National Academy of Sciences, show that aldosterone production is mediated by a protein called beta-arrestin-1. Beta-arrestin-1 binds to angiotensin II receptors when they are activated by...


Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'