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Latest Glucocorticoid Stories

2013-11-25 09:48:09

Steroid injections given to pregnant women before premature birth may increase the child's risk of later behavioral and emotional difficulties, a study has found. Mothers who are expected to give birth prematurely are often given an infusion of glucocorticoids, which mimic the natural hormone cortisol. This treatment is vital for helping the baby's lungs mature, but the new research suggests it may also increase the risk of mental health problems including attention-deficit/hyperactivity...

Search For New Drug Treatments With Help From Depressed Fish
2013-08-05 12:19:23

Max Planck Institute Antidepressant normalizes the behavior of zebrafish with a defective stress hormone receptor Chronic stress can lead to depression and anxiety in humans. Scientists working with Herwig Baier, Director at the Max Planck Institute of Neurobiology in Martinsried, recently discovered a very similar link in fish. Normally, the stress hormone cortisol helps fish, as in humans, to regulate stress. Fish that lack the receptor for cortisol as a result of a genetic mutation...

2013-07-19 15:43:59

A surprisingly large number of dogs suffer from hyperadrenocorticism.  The symptoms are caused by excessive amounts of hormones – glucocorticoids – in the body.  Unfortunately, though, diagnosis of the disease is complicated by the fact that glucocorticoid levels naturally fluctuate and most methods for measuring the concentration of the hormones in the blood provide only a snapshot of the current situation.  Recent...

2013-06-10 12:57:45

Researchers at Whitehead Institute have identified a protein that is the target of glucocorticoids, the drugs that are used to increase red blood cell production in patients with certain types of anemia, including those resulting from trauma, sepsis, malaria, kidney dialysis, and chemotherapy. The discovery could spur development of drugs capable of increasing this protein's production without causing the severe side effects associated with glucocorticoids. "This research is medically...

2013-03-13 17:47:27

On the football field, the neophyte fan focuses on the receiver, whose daring catch and dash for the goal line captures the attention. However, focusing on that one player means the fan misses the contributions of the quarterback, the blockers and the other players who make that run happen. The same is true in the cell, where too often a single finding about one protein, enzyme or receptor seems to solve a problem. In an online report in the journal Nucleic Acids Research, Dr. Michael...

2012-10-15 15:18:05

Georgia Health Sciences University researchers have developed a mouse that errs on the side of making bone rather than fat, which could eventually lead to better drugs to treat inflammatory diseases such as rheumatoid arthritis. Drugs commonly used to treat those types of conditions — called glucocorticoids — work by turning down the body's anti-inflammatory response, but simultaneously turn on other pathways that lead to bone loss. The result can lead to osteoporosis and an...

2012-09-20 16:56:31

In the body's ongoing effort to maintain a healthy weight, an arsenal of cellular proteins called androgen receptors is critical for blocking fat accumulation. Now researchers reporting in the September issue of the Cell Press Journal Chemistry & Biology have discovered that naturally occurring steroids called glucocorticoids can thwart the receptors' activity, ultimately encouraging fat buildup. "This has implications in this era of an obesity epidemic," says senior author Dr. Michael...

2012-09-20 16:52:24

The androgen receptor in human cells inhibits fat accumulation, but its activity can be sabotaged by glucocorticoids, steroids that regulate fat deposition and are known drivers of obesity and insulin resistance, said researchers led by those at Baylor College of Medicine (www.bcm.edu) in a report in the journal Chemistry & Biology (https://www.cell.com/chemistry-biology/home). "The project started with a straightforward search for genes or signals specific to human fat cells," said...

2012-07-13 10:38:25

An important breakthrough by IRCM researchers contributes to a better understanding of the human genome Researchers at the IRCM, led by geneticist Dr. Jacques Drouin, recently defined the interaction between two essential proteins that control inflammation. This important breakthrough will be published in tomorrow's print edition of the scientific journal Molecular Cell. IRCM scientists study glucocorticoids, a class of steroid hormones that suppress the immune system and reduce...

2012-04-24 12:37:03

A cellular protein called HDAC6, newly characterized as a gatekeeper of steroid biology in the brain, may provide a novel target for treating and preventing stress-linked disorders, such as depression and post-traumatic stress disorder (PTSD), according to research from the Perelman School of Medicine at the University of Pennsylvania. Glucocorticoids are natural steroids secreted by the body during stress. A small amount of these hormones helps with normal brain function, but their excess...


Word of the Day
penuche
  • A fudgelike confection of brown sugar, cream or milk, and chopped nuts.
'Penuche' is a variant of 'panocha,' a coarse grade of sugar made in Mexico. 'Panocha' probably comes from the Spanish 'panoja, panocha,' ear of grain.
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