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Latest Glucocorticoid Stories

2011-09-12 05:16:36

(Ivanhoe Newswire)--- By the year 2030, an estimated 67 million people will have doctor-diagnosed arthritis. But a commonly used drug may be able to prevent arthritis from happening to you. Many individuals develop arthritis from severe joint injuries. Young people are especially prone to these joint injuries because they are so active playing sports, or even skiing; activities that can cause damage to ligaments. A new study from MIT suggests that a drug that is used today to treat...

2011-07-18 15:08:00

GRAND RAPIDS, Mich., July 18, 2011 /PRNewswire/ -- In a study published recently in the journal Science Signaling Van Andel Research Institute (VARI) scientists demonstrate on the molecular level how the anti-malaria drug chloroquine represses inflammation, which may provide a blueprint for new strategies for treating inflammation and a multitude of autoimmune diseases such as arthritis, multiple sclerosis, and certain cancers. "The implications of this study are significant," said Henry...

2011-07-18 16:13:53

Anti-malaria drug provides key insight into potential treatments for autoimmune diseases In a study published recently in the journal Science Signaling Van Andel Research Institute (VARI) scientists demonstrate on the molecular level how the anti-malaria drug chloroquine represses inflammation, which may provide a blueprint for new strategies for treating inflammation and a multitude of autoimmune diseases such as arthritis, multiple sclerosis, and certain cancers. Chloroquine is a widely...

2011-07-07 19:08:09

Mice without cortisol receptor lose weight and suffer from gallstones Nature sees to it that we do not have "too much choler" (bile) in our body. A delicately equilibrated regulation system ensures that there is always exactly the right amount of bile in the gallbladder. When we are hungry, our body releases a hormone called cortisol, which is a glucocorticoid. Hepatic cells receive this hormone signal through their cortisol receptors (glucocorticoid receptors) and respond by filling the...

2011-06-06 14:50:26

Overexposure to stress hormones in the womb can program the potential for adverse health effects in those children and the next generation, but effects vary depending on whether the mother or father transmits them, a new animal study suggests. The results will be presented Saturday at The Endocrine Society's 93rd Annual Meeting in Boston. "This research sheds light on how babies who are exposed in the womb to excessive levels of stress hormones, known as glucocorticoids, can pass on the...

2011-04-05 08:00:00

CAMBRIDGE, Mass., April 5, 2011 /PRNewswire/ -- Tolerx, Inc., a biopharmaceutical company developing novel therapies to treat autoimmune diseases and cancer by normalizing the immune response, today presented results from preclinical studies with 2F8, a murine analog of TRX518, a first-in-class immunomodulatory agent currently in a Phase 1 clinical study for the treatment of cancer. Preclinical data demonstrated anti-tumor efficacy in a murine model as a monotherapy, and further enhanced...

2010-12-01 22:33:37

Glucocorticoid drugs are used widely to treat numerous conditions, including rheumatoid arthritis, allergic reactions, asthma, and some forms of cancer, and transplant recipients. The beneficial effects of these drugs are their potent antiinflammatory and immunosuppressive properties. However, their long-term use is limited by severe side effects, including high blood levels of glucose, fatty liver, and type 2 diabetes. A team of researchers, led by Carolyn Cummins, at the University of...

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2010-11-30 09:47:04

Any dog or cat owner will agree that animals have personalities but it may come as a surprise to many to learn that birds also do.  As an example, individual birds vary in their levels of curiosity, with distinctions being made between "fast" and "slow" explorers.  A considerable body of research has examined the differences between fast and slow birds but the levels of stress hormones (glucocorticoids) have not previously been investigated, although these hormones are known to be...

2010-09-08 14:00:28

    * Alcohol consumption, withdrawal, and abstinence can all raise stress hormones in humans and animals.    * A review has described how stress hormones called glucocorticoids are associated with neurotoxicity during abstinence after withdrawal from alcohol dependence.    * Glucocorticoid receptor antagonism may therefore represent a pharmacological option for recovery. Both drinking and withdrawal from chronic drinking can raise circulating...

2010-06-25 07:00:00

CAMBRIDGE, Mass., June 25 /PRNewswire/ -- Tolerx, Inc., a biopharmaceutical company developing novel therapies to treat autoimmune diseases and cancer by modulating T cell activity, presented results from preclinical studies with TRX518, an early-stage agent Tolerx is developing as a treatment for cancer. TRX518 is a monoclonal antibody to glucocorticoid-induced tumor necrosis factor receptor (GITR) and is designed to enhance the immune system's ability to attack tumors by activating and...


Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.