Quantcast

Latest Glucocorticoid Stories

94af112323d691077bf1d3c3c3710ca81
2010-05-18 07:13:09

Stages from Early to Mature Cell Offer Clues for Anti-Obesity Drug Development, Penn Researchers Report Getting from point A to B may sound simple, but not so in the formation of fat cells. In a finding with potential drug-development implications, Mitchell A. Lazar, M.D., Ph.D., director of the Institute for Diabetes, Obesity, and Metabolism at the University of Pennsylvania School of Medicine, and colleagues report in the current issue of Genes & Development the discovery of an...

2009-10-27 08:31:32

Dartmouth studies glucorticoid side effects In her most recent study of possible triggers of cancer among northern New England residents, Dartmouth epidemiologist Margaret R. Karagas, Ph.D., and her team identified an enhanced risk to the bladders of patients taking drugs that suppress the immune system. The findings, from a population-based, case-control study in New Hampshire, appear in the September 2009 issue of the British Journal of Cancer, with Dartmouth Medical School student Karl...

2009-07-23 09:44:00

INDIANAPOLIS, July 23 /PRNewswire-FirstCall/ -- Today, Eli Lilly and Company (NYSE: LLY) announced that the U.S. Food and Drug Administration (FDA) has approved a new use for its osteoporosis drug FORTEO((R)) [teriparatide (rDNA origin) injection] to treat osteoporosis associated with sustained, systemic glucocorticoid therapy in men and women at high risk of fracture. Glucocorticoid therapy is the most common cause of secondary osteoporosis, leading to bone loss and an increased risk for...

2008-11-18 12:05:22

Some drugs used in premature babies and in pregnant women at risk for preterm deliveries can kill infant brain cells, research by U.S. scientists shows. The study indicated the class of steroid drugs, glucocorticoids, often used to help underdeveloped lungs in premature infants, irreversibly damaged baby mice's brain cells in the cerebellum, the area responsible for coordination and balance, USA Today reported. In the study, brain cells in mice died after treatments administered four to 10...

2008-10-27 15:00:27

Results to be presented today at the 2008 American College of Rheumatology Annual Scientific Meeting in San Francisco, USA Galapagos NV (Euronext: GLPG) announces that Nanocort has demonstrated safety as well as a faster and more pronounced decrease in rheumatoid arthritis disease symptoms compared to reference medication. These results were obtained in an investigator driven double-blind, placebo controlled Phase I/II trial completed earlier this year at the Rheumatology Department of...

2008-09-11 15:00:09

German scientists say they have determined what conditions cause the body to deposit fat in the liver, possible leading to a fatty liver condition. Scientists have known the body's own glucocorticoid hormones, such as cortisol, promote the development of fatty liver. Long-term cortisone therapies such as those used for asthma and other chronic inflammatory diseases also cause the triglyceride level in the liver to rise to dangerous levels. Now Assistant Professor Stephan Herzig at the...

2008-07-05 00:00:06

A small protein may have a big role in helping a person make more bone and less fat, researchers at the Medical College of Georgia said. Dr. Xingming Shi of the Medical College of Georgia Institute of Molecular Medicine and Genetics found the short-acting protein GILZ that appears to make this desirable shift, and wants to understand better how it does it -- with the long-term goal of targeted therapies for osteoporosis and obesity. The pathways are parallel, and the idea is if you can...

2008-06-14 03:00:00

By Toda, Masahiro Makino, Hiroaki; Kobayashi, Hidetoshi; Morimoto, Kanehisa ABSTRACT. The authors collected saliva samples from 15 married couples and 13 women staying with a female companion (N = 43) during an 8-day stay at a spa resort in Nagano, Japan. To examine changes in endocrinological stress markers, the authors evaluated participants' levels of salivary cortisol and chromogranin A (CgA) by enzyme-linked immunosorbent assay. By the eighth day, women staying with their husbands had...

2006-03-29 11:40:16

NEW YORK (Reuters Health) - It is known that stress exacerbates the symptoms of asthma in children, but the biological reason for this has been unknown. Now, scientists in Canada have discovered that a stressful home life diminishes the expression of certain proteins on the surface of cells that regulate airway responses and inflammation. "Collectively, these findings suggest that in children and adolescents with asthma, the quality of home life and family relationships are important...

2005-09-08 15:04:37

Several nuclear receptor proteins appear to overlap in their ability to exert anti-inflammatory effects, according to new research by scientists at the University of California, San Diego (UCSD). Nuclear receptors are important drug targets for a number of diseases, for example, glucocorticoid receptors for asthma and arthritis. But use of drugs targeting these receptors is sometimes limited by unwelcome side effects. The new findings may suggest a way to overcome this obstacle. In a paper...


Word of the Day
call-note
  • The call or cry of a bird or other animal to its mate or its young.
'Call-note' is newer than 'bird-call,' which originally referred to 'an instrument for imitating the note of birds' but now also refers to 'the song or cry of a bird.'
Related