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Latest Glucokinase Stories

2014-01-15 14:38:58

Despite having mild hyperglycemia for approximately 50 years, patients with a mutation in the gene encoding the enzyme glucokinase had a low prevalence of clinically significant vascular complications, findings that provide insights into the risks associated with isolated mild hyperglycemia, according to a study in the January 15 issue of JAMA. "In both type 1 and type 2 diabetes, hyperglycemia [abnormally high blood sugar] is associated with microvascular complications over time....

Type 1 Diabetes In Dogs Cured, Human Cure Could Soon Follow
2013-02-07 11:11:56

Lee Rannals for redOrbit.com — Your Universe Online Researchers have made leaps and bounds, claiming that they have created a cure for type-1 diabetes in dogs, paving the way for a human cure. Universitat Autònoma de Barcelona (UAB) scientists say they have shown for the first time that it is possible to cure diabetes in large animals, a huge step towards possibly finding a cure for humans. The cure consists of a single session of various injections in the animal's...

Appetite Heightened By Ingestion Of Fructose
2013-01-02 04:38:43

April Flowers for redOrbit.com - Your Universe Online A new study from Yale University School of Medicine examines possible factors regarding the association between fructose consumption and weight gain. The researchers used brain magnetic resonance imaging, which indicated that ingestion of glucose but not fructose reduces cerebral blood flow. Activity in brain regions that regulate appetite was also reduced. The participants reported an increase in feeling sated and full from the...

2012-04-09 09:28:25

Salk researchers find molecular switch that controls liver glucose production and may represent a new avenue for treating insulin-resistant type II diabetes In their extraordinary quest to decode human metabolism, researchers at the Salk Institute for Biological Studies have discovered a pair of molecules that regulates the liver's production of glucose---- the simple sugar that is the source of energy in human cells and the central player in diabetes. In a paper published April 8 in...

2011-11-07 17:17:28

Researchers at Albert Einstein College of Medicine of Yeshiva University have demonstrated for the first time that the brain is a key player in regulating glucose (sugar) metabolism in humans. The findings, published today in the online edition of the Journal of Clinical Investigation, suggest that drugs targeting the brain and central nervous system could be a novel approach to treating diabetes. "The brain is the body's only organ that needs a constant supply of glucose to survive, so it...

2011-09-12 14:17:33

Say Hebrew University researchers Researchers at the Hebrew University of Jerusalem have identified the key signal that prompts production of insulin-producing beta cells in the pancreas -- a breakthrough discovery that may ultimately help researchers find ways to restore or increase beta cell function in people with type 1 diabetes. The work on the multi-year project was led by Prof. Yuval Dor of the Institute for Medical Research Israel-Canada of the Hebrew University, researchers...

2010-10-12 12:41:00

CHARLOTTESVILLE, Va., Oct. 12 /PRNewswire/ -- Beta-Pro LLC, announced today that it has expanded its operations to accommodate increasing demands from pharmaceutical drug discovery and research institutes in the $2 billion hepatocyte market. The human cellular sciences company now manages extensive laboratory facilities in the University of Virginia Research Park in Charlottesville, Virginia. "Beta-Pro has already established a foothold in the human pancreatic islet cell market and has...

2010-01-21 16:59:15

Understanding mechanism underlying SIRT6 activity may help treat diabetes, cancer A study investigating how a cellular enzyme affects blood glucose levels in mice provides clues to pathways that may be involved in processes including the regulation of longevity and the proliferation of tumor cells. In their report in the January 22 issue of Cell, a Massachusetts General Hospital (MGH)-based team of researchers describes the mechanism by which absence of the enzyme SIRT6 induces a fatal drop...

2009-12-14 17:15:00

BOULDER, Colo. and THOUSAND OAKS, Calif., Dec. 14 /PRNewswire-FirstCall/ -- Array BioPharma Inc. (Nasdaq: ARRY) and Amgen Inc.(Nasdaq: AMGN) today announced that they entered into an agreement granting Amgen exclusive worldwide rights to Array's small-molecule glucokinase activator program, including ARRY-403, currently being tested in a Phase 1 clinical trial in patients with Type 2 diabetes. Under the terms of the agreement, Array will receive an upfront payment of $60 million and...

2008-09-26 12:00:35

Array BioPharma, a biopharmaceutical company, has reported positive preclinical data of a novel small molecule glucokinase activator, ARRY-403, a drug for the treatment of Type 2 diabetes. The data showed that in multiple well-established in vivo models of Type 2 diabetes, ARRY-403 was highly efficacious in controlling both fasting and non-fasting glucose, with rapid onset of effect and maximal efficacy within five to eight days. In combination with existing standard-of-care drugs...