Latest Gluten-sensitive enteropathy associated conditions Stories
Researchers find new risk regions associated with primary biliary cirrhosis Researchers have newly identified three genetic regions associated with primary biliary cirrhosis (PBC), the most common autoimmune liver disease, increasing the number of known regions associated with the disorder to 25. The team used a DNA microchip, called Immunochip, to survey more thoroughly regions of the genome known to underlie other autoimmune diseases to discover if they play a role also in PBC...
A recent study demonstrated increased rates of celiac disease in women who present with unexplained infertility. Published in the May-June 2011 issue of The Journal of Reproductive Medicine, the study evaluated 191 female patients presenting with infertility. Each participant underwent serologic screening for celiac disease as well as routine infertility testing. The 4 patients who had positive serum test results were advised to seek evaluation with a gastroenterologist. All 4 patients were...
(Ivanhoe Newswire) -- New research shows patients with a recent onset of Parkinson's disease have a high rate of vitamin D insufficiency. However, this new study shows vitamin D concentrations do not appear to decline during the progression of the neurological disease.Vitamin D insufficiency has been linked to a variety of disorders and chronic diseases included multiple sclerosis, diabetes, and cancer. Previous studies have shown insufficient amounts of vitamin D are more common in patients...
An investigation has found that celiac disease and Crohn's disease, both inflammatory diseases of the gastrointestinal tract, share at least four genetic risk loci. Together, researchers from the University of Groningen, The Netherlands; the Broad Institute, USA; the Université de Montréal and Montreal Heart Institute in Canada performed a combined meta-analysis of genome-wide data for celiac disease and Crohn's disease. This meta-analysis, published in the open-access journal PLoS...
(Ivanhoe Newswire) -- A recent study has shown that celiac disease and Crohn's disease, both inflammatory diseases of the gastrointestinal tract, share at least four genetic risk loci.Researchers from the University of Groningen, The Netherlands; the Broad Institute, USA; and the Université de Montréal and Montreal Heart Institute in Canada collectively performed a pooled meta-analysis of genome-wide data for celiac disease and Crohn's disease. This meta-analysis has furthermore...
New research has identified four aspects of immune system disturbance which lead to the development of celiac disease. Nearly 40 different inherited risk factors which predispose to the disease have now been identified. These latest findings could speed the way towards improved diagnostics and treatments for the autoimmune complaint that affects 1 in 100 of the population, and lead to insights into related conditions such as type 1 diabetes.David van Heel, Professor of Gastrointestinal...
New research indicates that patients with lesser degrees of celiac disease-related symptoms, such as intestinal inflammation or latent celiac disease, have a modestly increased risk of death, according to a study in the September 16 issue of JAMA."Celiac disease is an immune-mediated disorder that is triggered by gluten exposure in genetically sensitive individuals, occurring in about 1 percent of the Western population," according to background information in the article. It causes...
A digestive disease caused by an immune response to gluten in wheat, barely, or rye is not only growing in prevalence, but leading to a higher rate of death for people who have it but don't know it.Those are the key findings from Mayo Clinic researchers who tested blood samples collected at an Air Force base in Wyoming in the late 1940s and early 1950s for celiac disease, then compared the results to blood tests for people today who were the same age as those in the earlier sample and those...
Alvine Pharmaceuticals, Inc., today announced proof of concept in a Phase 1 Trial of ALV003, an oral protease therapy in development to detoxify gluten, intended for use by patients with celiac disease. The trial results confirmed that single doses of up to 1,800 mg of ALV003 were safe and tolerable in healthy volunteers. Doses at the 300 mg level achieved up to a 96% reduction of gluten in a meal in the stomach at 30 minutes, and were well tolerated by patients with celiac disease. In...
By McGowan, Kelly E Lyon, Martha E; Butzner, J Decker BACKGROUND: IgA deficiency causes false-negative IgAbased celiac serology results in patients with celiac disease. Using a case- finding strategy, we examined the prevalence of IgA deficiency, physician evaluation, and management of IgA deficiency during serological testing for celiac disease. METHODS: We reviewed consecutive IgA-endomysial antibody (EMA) and serum IgA results from the laboratory database over 17 months. We...
