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Latest Glycomics Stories

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2010-05-31 07:32:46

Researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC), Berkeley, have successfully attached imaging probes to glycans "“ the sugar molecules that are abundant on the surfaces of living cells "“ in the embryos of zebrafish less than seven hours after fertilization. Glycans are key regulators of the processes that guide cell development, and zebrafish are a top vertebrate model organism of...

2010-05-24 07:19:44

Scientists some years back found ways to automate the production of DNA and proteins, making studies of these essential components of life far easier. With complex carbohydrates, it's been a different story. Until now, the construction of so-called "libraries" of carbohydrate molecules for biological study has been slow and tedious. In what may change all that, a team of scientists from the University of Georgia has created a method for the rapid chemical synthesis of complex carbohydrates,...

2010-05-06 09:00:00

MILFORD, Mass. and DUBLIN, May 6 /PRNewswire/ -- Waters Corporation (NYSE : WAT) and Ireland's National Institute for Bioprocessing Research and Training (NIBRT) announced today a collaboration that will create the world's first database for glycan analysis by UltraPerformance Liquid Chromatography(®) (UPLC(®)). Expected to be available in 2011, NIBRT will develop, maintain and license the database while Waters and NIBRT will co-market it worldwide....

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2010-01-20 08:56:48

For the first time, the widely used molecular synthesis technique known as click chemistry has been safely applied to a living organism. Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have crafted a unique copper-free version of click chemistry to create biomolecular probes for in vivo studies of live mice. Conventional click chemistry reactions require a copper catalyst that is toxic to cells and organisms. "We developed a...

2009-07-13 10:33:12

U.S. researchers say they've discovered specialized complex sugar molecules called glycans can act as tumor suppressors in breast and prostate cancers. The Burnham Institute for Medical Research scientists said the glycans play a critical role in cell adhesion in normal cells, and their decrease or loss leads to increased cell migration by invasive cancer cells and metastasis. The researchers, led by Professor Minoru Fukuda, said an increase in expression of the enzyme that produces the...

2009-07-07 11:59:17

 Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specialized complex sugar molecules (glycans) that anchor cells into place act as tumor suppressors in breast and prostate cancers. These glycans play a critical role in cell adhesion in normal cells, and their decrease or loss leads to increased cell migration by invasive cancer cells and metastasis. An increase in expression of the enzyme that produces these glycans, ÃŽ²3GnT1, resulted...

2009-03-26 11:09:00

German scientists say they have created an automated carbohydrate synthesizer that can create carbohydrate molecules within only a few hours. Professor Peter Seeberger of the Max-Planck Institute for Colloids and Interfaces in Potsdam, Germany, and the Free University of Berlin described the synthesizer in Salt Lake City this week during a meeting of the American Chemical Society. Our automated synthesizer is now the fastest method to make complex carbohydrates, said Seeberger, principal...

2008-09-08 09:00:12

By James Thalman Deseret News University of Utah scientists may have solved an old biology riddle: How do you better understand the workings of a carbohydrate molecule critical to human health without damaging the cellular function that produces it? Research of proteoglycans, one of the most important type of carbohydrates known as glycoconjugates, has been somewhat stymied in efforts to understand what happens inside a cell when this particular glycoconjugate isn't produced. Scientists...

2008-08-09 03:00:09

By Kyselova, Zuzana Mechref, Yehia; Kang, Pilsoo; Goetz, John A; Dobrolecki, Lacey E; Sledge, George W; Schnaper, Lauren; Hickey, Robert J; Malkas, Linda H; Novotny, Milos V BACKGROUND: Glycosylated proteins play important roles in cell- to-cell interactions, immunosurveillance, and a variety of receptor- mediated and specific protein functions through a highly complex repertoire of glycan structures. Aberrant glycosylation has been implicated in cancer for many years. METHODS: We performed...

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2008-01-17 09:05:21

Glycoscience now hotbed of medical research Sugars were once credited with magical healing powers but are now seen like salt as an evil necessary in small doses but the cause of numerous diseases such as diabetes if taken in excess. Yet latest research suggests this view ignores the vital role played by more complex sugars in many biological structures, and the great therapeutic potential they have. This all emerged in a recent workshop organised by the European Science Foundation (ESF) on...


Word of the Day
cacodemon
  • An evil spirit; a devil.
  • A nightmare.
  • In astrology, the twelfth house of a scheme or figure of the heavens: so called from its signifying dreadful things, such as secret enemies, great losses, imprisonment, etc.
'Cacodemon' comes from a Greek term meaning 'evil genius.'
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