Latest Gp41 Stories

2014-04-24 12:30:09

NEW YORK, April 24, 2014 /PRNewswire-USNewswire/ -- Scientists from The Scripps Research Institute (TSRI) and the International AIDS Vaccine Initiative (IAVI) have discovered a new vulnerable site on HIV that antibodies can attack to prevent infection from a broad range of the virus' many variants. http://photos.prnewswire.com/prnvar/20131210/DC30761LOGO "HIV has very few known sites of vulnerability, but in this work we've described a new one, and we expect it will be useful in developing a...

2011-10-13 20:49:44

The findings advance AIDS vaccine development Researchers at The Scripps Research Institute have uncovered the surprising details of how a powerful anti-HIV antibody grabs hold of the virus. The findings, published in Science Express on October 13, 2011, highlight a major vulnerability of HIV and suggest a new target for vaccine development. "What's unexpected and unique about this antibody is that it not only attaches to the sugar coating of the virus but also reaches through to grab...

2010-11-19 12:14:47

Researchers have been stymied for years over the fact that people infected with the AIDS virus do indeed produce antibodies in response to the pathogen "“ antibodies that turn out to be ineffective in blocking infection. Now, scientists at Duke University Medical Center can explain why: Some of the earliest and most abundant antibodies available to fight HIV can't actually "see" the virus until after it's already invaded a healthy cell. The scientists based their conclusion on the...

2009-11-30 16:18:05

Publishing in PLoS Pathogens, researchers at from the Kimmel Cancer Center at Jefferson have found a novel mechanism by which drugs block HIV-1 from entering host cells. Cellular invasion by HIV-1 requires the concerted action of two proteins on the viral surface: gp120 and gp41. The function of gp41 is to get the viral contents into the interior of the host cells. This requires the association of two distinct regions of gp41 called N-HR and C-HR. Anti-HIV-1 agents known as fusion inhibitors...

2006-05-24 13:29:50

By Patricia Reaney LONDON (Reuters) - Scientists in the United States have taken a close up, three-dimensional look at spike proteins on the surface of the AIDS virus which could speed up the search for a vaccine. The proteins, known as gp120 and gp41, allow HIV which causes AIDS to bind and fuse with human cells. "We've got the first really good look of what the whole virus looks like to the point that we can see the spikes on the surface of the virus," Professor Kenneth Roux, of...

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