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Latest Granzyme Stories

2014-02-10 11:17:25

Twenty proteins specifically secreted by primary effusion lymphoma cell lines identified, according to new research published in The American Journal of Pathology Primary effusion lymphoma (PEL) is a rare B-cell neoplasm distinguished by its tendency to spread along the thin serous membranes that line body cavities without infiltrating or destroying nearby tissue. By growing PEL cells in culture and analyzing the secretome (proteins secreted into cell-conditioned media), investigators have...

Red Wine Compound Could Help Fight Prostate Cancer
2012-11-12 13:53:08

[ Watch the Video: Fighting Prostate Cancer with Red Wine ] Lee Rannals for redOrbit.com - Your Universe Online A compound in grape skins and red wine may be able to help fight off prostate cancer, according to a new study published in the Journal of Andrology and Cancer Science. Resveratrol, which is found in grape skins and red wine, has been shown to have several beneficial effects on human health in past studies, aiding cardiovascular health and stroke prevention. The latest...

2011-06-09 23:36:54

After eight years of work, researchers have unearthed what has been a well-kept secret of our immune system's success. The findings published online on June 9th in Immunity, a Cell Press publication, offer an explanation for how specialized immune cells are able to kill infected or cancerous cells without killing themselves in the process. The focus of the study is a molecule known as perforin, whose job it is to open up a pore in cells targeted for destruction. With that pore in place,...

2011-03-02 20:20:11

Work led by St. Jude Children's Research Hospital investigators provides fresh insight into mechanisms controlling programmed cell death pathways and offers new targets in the fight against cancer and virus-infected cells Work led by St. Jude Children's Research Hospital scientists identified how cells flip a switch between cell survival and cell death that involves a protein called FLIP. The findings solve a riddle that has puzzled scientists for more than a decade regarding the dual nature...

2010-01-27 16:49:35

New research findings from a team at the Providence Heart + Lung Institute at St. Paul's Hospital and the University of British Columbia (UBC) may lead to new treatment options for abdominal aortic aneurysms (AAA) "“ a potentially fatal disease that currently has no pharmacological treatments. An aortic aneurysm is a bulging of the aorta, the largest blood vessel in the body. If the aneurysm ruptures, it causes rapid blood loss and a high risk of death. About 75 per cent of all aortic...

2009-10-16 10:35:48

A series of studies have demonstrated that Chrysanthemum indicum possesses antimicrobial, antiinflammatory, immunomodulatory, and neuroprotective effects. Recently, much attention has been devoted to the anticancer activity of Chrysanthemum indicum, especially in hepatocellular carcinoma (HCC). However, its anticancer mechanism of action is still not clear and needs further investigation. A research article to be published on September 28, 2009 in the World Journal of Gastroenterology...

2009-09-21 13:47:42

Caspase-3 Cleaves in Unforeseen Ways Investigators at Burnham Institute for Medical Research (Burnham) have identified novel cleavage sites for the enzyme caspase-3 (an enzyme that proteolytically cleaves target proteins). Using an advanced proteomic technique called N-terminomics, Guy Salvesen, Ph.D., professor and director of the Apoptosis and Cell Death Research program of Burnham's NCI-designated Cancer Center, and colleagues determined the cleavage sites on target proteins and found,...


Word of the Day
siliqua
  • A Roman unit of weight, 1⁄1728 of a pound.
  • A weight of four grains used in weighing gold and precious stones; a carat.
  • In anatomy, a formation suggesting a husk or pod.
  • The lowest unit in the Roman coinage, the twenty-fourth part of a solidus.
  • A coin of base silver of the Gothic and Lombard kings of Italy.
'Siliqua' comes from a Latin word meaning 'a pod.'
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