Latest GSK-3 Stories

2012-03-13 23:34:00

Scientists have gained insight into why lithium salts are effective at treating bipolar disorder in what could lead to more targeted therapies with fewer side-effects. Bipolar disorder is characterised by alternating states of elevated mood, or mania, and depression. It affects between 1% and 3% of the general population. The extreme 'mood swings' in bipolar disorder have been strongly associated with disruptions in circadian rhythms — the 24-hourly rhythms controlled by our body...

2011-11-17 10:57:59

Significant progress has been made in understanding the genetic risk factors underlying psychiatric disease. Recent studies have identified common genetic mutations conferring modest risk and rare variants comprising significant risk. One example of a rare cause of psychiatric disorders is the Disrupted in Schizophrenia-1 (DISC1) gene, first identified in a large Scottish pedigree displaying schizophrenia, bipolar disorder and depression. Common variants in DISC1 have been associated with...

2010-07-15 02:43:36

Scientists are making progress towards a better understanding of the neuropathology associated with debilitating psychiatric illnesses like bipolar disorder and schizophrenia. New research, published by Cell Press in the July 15 issue of the journal Neuron, reveals mechanisms that connect a known psychiatric risk gene to disruptions in brain cell proliferation and migration during development. A research group led by Dr. Li-Huei Tsai from the Massachusetts Institute of Technology had recently...

2010-06-08 15:30:12

Lithium is the most effective treatment for bipolar disorder. However, its use is limited because of neurological side effects and a risk for overdose-induced toxicity. Many of the beneficial effects of lithium are mediated by its inhibition of GSK-3 proteins, but whether this is the mechanism underlying its negative effects has not been determined. However, Raquel G³mez-Sintes and Jos© Lucas, at CSIC/UAM, Spain, have now delineated a molecular pathway by which chronic...

2008-03-18 15:49:15

Study first to show biopolar drug could effectively treat inclusion body myositis A new UC Irvine study finds that lithium chloride, a drug used to treat bipolar disorder, can slow the development of inclusion body myositis, a skeletal muscle disease that affects the elderly.In the study by scientists Frank LaFerla and Masashi Kitazawa, mice genetically engineered to have IBM demonstrated markedly better motor function six months after receiving daily doses of lithium chloride, compared with...

Word of the Day
  • A stinking tobacco.
  • Offal; waste animal product; organic matter unfit for consumption.
This word comes from the Spanish 'mondongo,' tripe, entrails.