Latest Guanidines Stories

With the H1N1 flu outbreak now elevated to pandemic level, a new article http://www.cmaj.ca/cgi/rapidpdf/cmaj.090866 in CMAJ (Canadian Medical Association Journal) reports that oseltamivir (Tamiflu®) and zanamivir (Relenza®) are relatively safe drugs for use in pregnant and breast-feeding women.Pregnant women, especially those in the third trimester, are at high risk of serious complications from the H1N1 A influenza virus.The study was conducted by researchers from the Motherisk...

Taking the diabetes medications metformin and rosiglitazone together reverses the adverse effects on bone of rosiglitazone treatment alone in an experimental model, according to a new study done in rats. The results were presented at The Endocrine Society's 91st Annual Meeting in Washington, D.C.Both metformin and rosiglitazone are widely used in the treatment of type 2 diabetes and the metabolic syndrome, said lead author Claudia Sedlinsky, MD, of GIOMM - La Plata National University, La...

- Company preparing to initiate phase III trial - SOUTH SAN FRANCISCO, Calif., March 30 /PRNewswire/ -- Hyperion Therapeutics, Inc. today announced top-line results from their phase II study of HPN-100 for the treatment of urea cycle disorders. The data was presented on March 27th at the 16th Annual Clinical Genetics Meeting of the American College of Medical Genetics by Brendan Lee, M.D., Ph.D., Howard Hughes Medical Institute Investigator and Professor Department of Molecular and Human...

An amino acid found in watermelon juice, nuts and other foods may fight obesity, U.S. researchers say. The study, published in the Journal of Nutrition, finds rats fed either low-fat or high-fat diets supplemented with the amino acid arginine over a 12-week period decreased body fat by over 60 percent. This finding could be directly translated into fighting human obesity. At this time, arginine has not been incorporated into our food but could in the future, study leader Guoyao Wu of Texas...

A Texas AgriLife Research scientist and fellow researchers have discovered that arginine, an amino acid, reduces fat mass in diet-induced obese rats and could help fight human obesity."Given the current epidemic of obesity in the U.S. and worldwide, our finding is very important," said Dr. Guoyao Wu, an AgriLife Research animal nutritionist in College Station and Senior Faculty Fellow in the department of animal science at Texas A&M University.The research found dietary arginine...

Swedish researchers have found that an enzyme that aids sexual performance in human males helps spruce trees develop stronger root systems. A team led by Torgny Nasholm, a forestry professor at the Swedish University of the Agricultural Sciences, created a fertilizer laced with arginine, Vasterbotten-Kurrien reported. The enzyme improves sperm production and blood circulation in the genital area. Nasholm found that trees given the fertilizer had stronger root systems. As an additional...

SOUTH SAN FRANCISCO, Calif., Nov. 12 /PRNewswire/ -- Hyperion Therapeutics, Inc. today reported completion of data analysis for its Phase 2 clinical trial designed to evaluate the safety, tolerability and ammonia scavenging effects of HPN-100 versus BUPHENYL(R) (sodium phenylbutyrate), the current standard of care in patients with urea cycle disorders. Data from the trial will be presented at an upcoming medical conference. (Logo: http://www.newscom.com/cgi-bin/prnh/20070905/AQW076LOGO)...

Genaera, a biopharmaceutical company, has reported data from its second Phase I clinical trial of trodusquemine, the company's lead drug candidate for the treatment of type 2 diabetes and obesity. In the study, trodusquemine (MSI-1436) was found to be well-tolerated and no serious adverse events were experienced at likely clinical doses. There were indications of dose-dependent weight loss seen in the obese and overweight type 2 diabetic subjects. Study MSI-1436C-103 was a double-blind,...

Reportlinker.com announces that a new market research report related to the Agricultural chemicals industry is available in its catalogue. Production and market of imidacloprid in China http://www.reportlinker.com/p096339/Production-and-market-of-imidacloprid-in-China.html Imidacloprid, a kind of chloronicotinyl insecticides, is the third largest insecticide in the world, only next to organophosphorus insecticide and pyrethroid insecticide. The sales volume of imidacloprid is the largest...

Bristol-Myers Squibb Company and AstraZeneca have presented promising results from a 24-week Phase III study of saxagliptin, an investigational DPP-4 inhibitor in development for the treatment of type 2 diabetes. Results from a 24-week Phase III study have demonstrated that saxagliptin, when used in combination with metformin as an initial therapy, produced reductions across all key measures of glucose control studied (glycosylated hemoglobin level (A1C), fasting plasma glucose and...