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Latest Hedgehog signaling pathway Stories

2011-10-24 09:25:24

CK1 protein in cancer cells identified as possible future therapeutic target Researchers from the NYU Cancer Institute, an NCI-designated cancer center at NYU Langone Medical Center, have identified a cell cycle-regulated mechanism behind the transformation of normal cells into cancerous cells. The study shows the significant role that protein networks can play in a cell leading to the development of cancer. The study results, published in the October 21 issue of the journal Molecular...

2011-09-01 17:08:32

Salk scientists discover a highly conserved mechanism governing brain development If you think today's political rhetoric is overheated, imagine what goes on inside a vertebrate embryo. There, two armies whose agendas are poles apart, engage in a battle with consequences much more dire than whether the economy will recover---- they are battling for whether you (or frogs or chickens) will have a forebrain. In a study published in the August 19 online edition of Genes & Development,...

2011-07-28 00:56:17

New research may help to explain why the location of postnatal neural stem cells in the brain determines the type of new neurons that are generated. The research, published by Cell Press in the July 28 issue of the journal Neuron, demonstrates that a signaling pathway which plays a key role in development also actively regulates the fate of neural stem cells in the adult brain. Manipulation of this signaling pathway redirected the fate of adult stem cells, a finding that may impact the design...

2011-07-07 15:24:48

Researchers examine how genes and proteins affect therapeutic treatments The Translational Genomics Research Institute (TGen) is presenting two key studies, including one today, at the 14th World Conference on Lung Cancer, July 3-7 in Amsterdam. One study, presented July 4, involved a gene called GLI1, which may limit the effectiveness of the most common combination chemotherapy given to patients with small cell lung cancer (SCLC). Another study, presented today, July 7, suggests that...

2011-06-02 16:13:35

While it is already known that breast cancer cells create the conditions for their own survival by communicating their needs to the healthy cells that surround them, Australian researchers have identified a new way of turning off that cellular cross talk. They have shown that a molecule known as 'hedgehog' sits at the centre of the switchboard in breast cancer, transmitting biochemical signals between the cancer cells and healthy cells. When this conversation is blocked "“ or hedgehog...

2011-04-13 21:05:19

NYU School of Medicine researchers find molecules block a crucial cell pathway Researchers from the Cancer Institute at NYU Langone Medical Center have identified three novel small molecules that interrupt a crucial cellular communication pathway that regulates many aspects of development and cancer. The finding, published in the April 12, 2011 issue of the Proceedings of the National Academy of Sciences and featured on its cover, could provide the basis for innovative therapies for...

2011-04-04 14:00:00

ORLANDO, Fla., April 4, 2011 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) announced results today from two preclinical studies of molecules that target genetic mutations and disable specific signaling pathways that can lead to cancer. The studies evaluated two unique molecules - a JAK2 inhibitor and a Hedgehog inhibitor - with results presented during the American Association for Cancer Research (AACR) 102nd Annual Meeting in Orlando, Fla. Signaling pathways within cells regulate...

2011-04-03 15:49:29

A new hedgehog pathway inhibitor demonstrated efficacy in preventing and treating basal cell cancer among patients with basal cell nevus syndrome, a rare inheritable disease, according to Phase II data presented at the AACR 102nd Annual Meeting 2011, held April 2-6. In 1996, Ervin Epstein Jr., M.D., senior scientist at Children's Hospital of Oakland Research Institute, and colleagues identified the site of the mutation that causes basal cell nevus syndrome: the PTCH gene, which encodes a...

2011-02-28 22:12:37

A pediatric brain tumor that causes gruesome suffering is finally yielding its secrets. For the first time, scientists at the Stanford University School of Medicine have cultured human cells from this cancer, Diffuse Intrinsic Pontine Glioma, and used those cells to create an animal model of the disease. Their discoveries will facilitate research on new treatments for DIPG, a tumor of school-aged children that is now almost universally fatal. The advances come thanks to the parents of young...

2011-01-10 15:07:49

Common genetic recipes pattern organs as different as shark gills and human hands A SCUBA expedition in Australia and New Zealand to find the rare embryos of an unusual shark cousin enabled American and British researchers to confirm new developmental similarities between fish and mammals. Elephant fish, a relative of sharks, utilize the same genetic process for forming skeletal gill covers that lizards and mammals use to form fingers and toes, researchers at the University of Chicago and the...