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Latest Hedgehog signaling pathway Stories

2010-06-07 13:42:09

Researchers from St. Jude Children's Research Hospital and the Pediatric Brain Tumor Consortium (PBTC) presented at the American Society of Clinical Oncology the findings of a pediatric brain tumor study using an experimental drug that targets the underlying genetic makeup of the tumor. The research focused on a new way to attack the tumors by blocking the Hedgehog pathway that is linked to approximately 20 percent of medulloblastomas. The study is the first to report that the drug can be...

2010-06-05 09:30:00

CHICAGO, June 5 /PRNewswire/ -- Researchers from St. Jude Children's Research Hospital and the Pediatric Brain Tumor Consortium (PBTC) presented today at the American Society of Clinical Oncology the findings of a pediatric brain tumor study using an experimental drug that targets the underlying genetic makeup of the tumor. The research focused on a new way to attack the tumors by blocking the Hedgehog pathway that is linked to approximately 20 percent of medulloblastomas. The study is the...

2010-03-10 08:31:22

Sonic hedgehog, a gene that plays a crucial rule in the positioning and growth of limbs, fingers and toes, has been confirmed in an unexpected place in the embryos of developing mice "” the layer of cells that creates the skin. Named for a video game character, Sonic hedgehog describes both a gene and the protein it produces in the body. Its study is important to increase understanding of human birth defects. It was thought to be exclusively present in the cell layer that builds bone...

2010-02-23 14:54:23

PHILADELPHIA "” Researchers have found a new oncogenic signaling pathway by which the environmental toxin arsenic may lead to adverse health effects, including bladder cancer. These study results are published in Cancer Research, a journal of the American Association for Cancer Research. "In a collaborative investigation we found that arsenic, at environmentally relevant levels, is capable of activating the Hedgehog pathway and may represent a novel pathway of arsenic-associated...

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2010-02-02 09:13:10

The role that the master gene Math1 plays in making a critical population of cells called granule neurons in the cerebellum also points to its involvement in the development of a common childhood brain tumor called medulloblastoma. This finding helps explain the continuous proliferation or reproduction of the tumor cells, said researchers from Baylor College of Medicine in a report in a recent issue of the journal Science. New target for treatment Understanding the role of Math1 could help...

2010-01-07 17:52:43

The laboratory of Dr. Fr©d©ric Charron, in Montreal, made this discovery The laboratory of Dr. Fr©d©ric Charron, a researcher at the Institut de recherches cliniques de Montr©al (IRCM), has discovered a new molecular mechanism that permits the guidance of visual nerves towards the brain. Their findings have been published in the current issue of the Journal of Neuroscience. The research was conducted in collaboration with Dr. Tomomi Shimogori from the RIKEN Brain...

2009-12-09 18:08:11

 Genetic variations in the Sonic Hedgehog pathway increase the likelihood of recurrence, reduce survival time and limit response to therapy for people with non-muscle invasive bladder cancer, scientists from The University of Texas M. D. Anderson Cancer Center reported today at the American Association for Cancer Research Frontiers in Cancer Prevention Research Conference. "These variations are strongly associated with response to standard immunotherapy that patients receive after tumor...

2009-12-03 22:15:00

The master gene Math1 is involved in the genesis of the most common childhood brain tumor, medulloblastoma, said researchers from Baylor College of Medicine (www.bcm.edu) in a report in the current issue of the journal Science. The finding provides a new treatment target in the deadly disease that most commonly affects children and young adults, said Dr. Huda Zoghbi (http://www.bcm.edu/pediatrics/index.cfm?Realm=99992437&This_Template=huda_zoghbi,...

2009-12-03 21:25:41

Howard Hughes Medical Institute (HHMI) researchers have identified a new factor that is necessary for the development of many forms of medulloblastoma, the most common type of malignant childhood brain cancer. HHMI investigator Huda Y. Zoghbi and colleagues at Baylor College of Medicine prevented medulloblastoma from developing in mice by shutting down production of the protein Atoh1 in susceptible brain cells. The team's findings, reported in the December 4, 2009, issue of Science, suggest...

2009-11-15 12:07:52

Researchers at the University of Wisconsin-Madison School of Medicine and Public Health have identified a molecular mechanism that allows two powerful signaling pathways to interact and begin a process leading to colorectal tumors. "We are very excited about these findings," says Vladimir Spiegelman, an associate professor of dermatology. "Drugs could be developed to block this mechanism and prevent colorectal cancer, which affects millions of people worldwide." The research will appear in...


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.