Latest Hedgehog signaling pathway Stories

Curis, Inc. (NASDAQ: CRIS), a drug development company focused on developing the next generation of proprietary targeted medicines for cancer treatment, today announced that its collaborator Genentech, Inc. has indicated that it expects to initiate a Phase II clinical trial of GDC-0449, an orally-administered small molecule Hedgehog antagonist, as a maintenance therapy for ovarian cancer patients in second or third complete remission. Genentech is developing GDC-0449 under a collaboration...

Curis, Inc. (NASDAQ: CRIS), a drug development company focused on developing next generation proprietary targeted medicines for cancer treatment, today announced the publication of preclinical data in Nature that support the premise that Hedgehog proteins play an important role in supporting tumor growth in Hedgehog-expressing solid tumors through a paracrine mechanism of action. The paper reported that analysis of human tissue samples by Genentech scientists revealed that subsets of...

Curis, Inc. (NASDAQ: CRIS), a drug development company focused on developing next generation proprietary targeted medicines for cancer treatment, today announced that the first patient has been treated in a Phase I clinical trial of CUDC-101, a first-in-class small molecule drug candidate that has been designed as an inhibitor of epidermal growth factor receptor (EGFR), epidermal growth factor receptor 2 (Her2) and histone deacetylase (HDAC). CUDC-101 has been designed to simultaneously...

Curis, Inc. (NASDAQ:CRIS), a drug development company focused on developing proprietary targeted medicines primarily for cancer treatment, today announced that the Company will release its second quarter financial results on Wednesday, July 30, 2008 before the market opens. The Company will also hold a conference call on the same day at 9:00 A.M. Eastern time to discuss: (i) its Hedgehog antagonist program under collaboration with Genentech, (ii) CUDC-101 and other proprietary targeted cancer...

U.S. medical scientists say a set of promising new anti-cancer agents called hedgehog antagonists might present a risk for people with heart disease. Researchers at the Washington University School of Medicine in St. Louis said the hedgehog antagonists interfere with a biochemical process called hedgehog signaling that promotes growth in some cancer cells. But the study showed interfering with that biochemical process in mice with heart disease led to further deterioration of cardiac...

MADISON - Researchers at the University of Wisconsin School of Medicine and Public Health (SMPH) are wagging a finger at currently held notions about the way digits are formed.Studying the embryonic chick foot, the developmental biologists have come up with a model that explains how digits grow and why each digit is different from the others. As reported in the Proceedings of the National Academy of Sciences Online Early Edition the week of March 10-14, 2008, the scientists found that the...

Curis, Inc. (NASDAQ: CRIS), a drug development company focused on seeking to develop proprietary targeted medicines primarily for cancer treatment, today announced that it has entered into an agreement to sell and assign its remaining BMP-7 technologies to Stryker Corporation. Curis' BMP-7 assets primarily comprise intellectual property covering bone morphogenetic protein-7, or BMP-7, and its use for treating various diseases. Curis will receive an initial payment of $1 million, which...

The Quaking gene, first described as a mutation in mice that causes rapid tremor, is thought to suppress tumor formation and protect humans from cancer. Now, a team of researchers from Northwestern University and the University of Wisconsin has shown that the Quaking gene likely suppresses tumor growth by inhibiting production of a protein associated with GLI1, a cancer-causing oncogene highly associated with severe birth defects and several childhood cancers. The group's study, published in...

New studies in mice have shown that immature stem cells that proliferate to form brain tissues can function for at least a year "” most of the life span of a mouse "” and give rise to multiple types of neural cells, not just neurons. The discovery may bode well for the use of these neural stem cells to regenerate brain tissue lost to injury or disease. Alexandra L. Joyner, a Howard Hughes Medical Institute investigator at New York University School of Medicine, and her former postdoctoral...

MADISON - Feathers are the essence of birds. Without them, birds could not fly or attract mates. But how exactly do feathers form molecularly? Experimentally testing one current hypothesis, developmental biologists at University of Wisconsin Medical School believe they now have the answer.In a previous study, UW anatomy professor John F. Fallon and his team showed that Sonic hedgehog (Shh) and bone morphogenetic protein 2 (Bmp2) must be expressed in order to produce barb ridges, which are...