Latest Helicase Stories
Borrelia burgdorferi, the bacterium that causes Lyme disease, hitchhikes in ticks for dissemination to mammalian hosts--including humans.
Breaks in the double-strands of the DNA helix can spell trouble, destabilizing the genome and resulting in changes that drive cancer, antibiotic resistance and, on a more positive note, evolution.
Building on earlier work exploring the complex choreography by which intricate cellular proteins interact with and copy DNA prior to cell division, scientists at the U.S. Department of Energy's Brookhaven National Laboratory and collaborators have captured a key step-molecular images showing how the enzyme that unwinds the DNA double helix gets drawn to and wrapped around its target.
Scientists have revealed how a bacterial enzyme has evolved an energy-efficient method to move long distances along DNA.
Molecular biologists at The University of Texas at Austin have solved one of the mysteries of how double-stranded RNA is remodeled inside cells in both their normal and disease states.
With an eye toward understanding DNA replication, Cornell researchers have learned how a helicase enzyme works to actually unzip the two strands of DNA.
Biologists at the University of California, San Diego have found another member in a new class of cellular motor proteins that rewind and seal together sections of the double-stranded DNA molecule that occasionally but perilously become unwound.
The atomic-level action of a remarkable class of ring-shaped protein motors has been uncovered by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) using a state-of-the-art protein crystallography beamline at the Advanced Light Source (ALS).
Two biologists at the University of California, San Diego have discovered the first of a new class of cellular motor proteins that "rewind" sections of the double-stranded DNA molecule that become unwound, like the tangled ribbons from a cassette tape, in "bubbles" that prevent critical genes from being expressed.
Enzymes called helicases play a key role in human health, according to Maria Spies, a University of Illinois biochemistry professor.