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Latest Hematopoietic stem cell Stories

2009-07-15 13:31:53

A Massachusetts General Hospital (MGH)-based research team has identified how a chromosomal abnormality known to be associated with acute lymphoblastic leukemia (ALL) "“ the most common cancer in children "“ initiates the disease process. In the July issue of Cell Stem Cell, they describe how expression of this mutation in hematopoietic stem cells (HSCs), which usually occurs before birth, leads to the development of leukemia many years later."Based on their longevity, it had been...

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2009-07-15 09:30:00

The research team led by Dr. Timm Schroeder, stem cell researcher at Helmholtz Zentrum Mnchen, has developed a new bioimaging method for observing the differentiation of hematopoietic progenitor cells (HPC) at the single-cell level. With this method the researchers were able to prove for the first time that not only cell-intrinsic mechanisms, but also external environmental factors such as growth factors can control HPC lineage choice directly. The findings, published in the current issue of...

2009-07-15 07:48:59

For decades scientists from various disciplines have discussed to what respective extent genetic predisposition and environmental factors influence human development. Likewise, the same "Ëœnature vs. nurture' issue is debated by hematologists and stem cell researchers: Is multipotent progenitor cell differentiation influenced solely by cell-intrinsic mechanisms or is it also influenced by the environment of the cell? What role do growth factors such as cytokines play? Do they...

2009-07-08 06:23:00

LA JOLLA, Calif., and BARCELONA, July 8 /PRNewswire/ -- Fate Therapeutics, Inc. announced today the presentation of data from its research on small molecule modulators of the Wnt pathway for osteo-regeneration at the 7th Annual Meeting of the International Society for Stem Cell Research (ISSCR) in Barcelona, Spain. In its findings, the Company demonstrated that selected Wnt activators induce the differentiation of mesenchymal stem cells to mature, bone-forming osteoblasts. The study...

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2009-06-24 15:35:00

Investigators at Children's Hospital Oakland Research Institute, Oakland, California found a way to obtain large numbers of hematopoietic stem cell from human term placenta. The results, which appear in the July 2009 issue of Experimental Biology and Medicine, describe detailed report on quantification, characterization, engraftment capacity, and most importantly, practical way to obtain hematopoietic stem cells from placenta in numbers that are several-fold higher than could be obtained from...

2009-06-03 09:36:00

JERUSALEM, June 3 /PRNewswire/ -- The Gamida Cell-Teva Joint Venture announced today that five prestigious cord blood transplantations centers in Spain, three in Barcelona and two in Valencia, have joined the Excel study. Participating clinical sites include, in alphabetical order: - Hospital Clinic of Barcelona, Barcelona Principal Investigator, Dr. Enric Carreras, MD - Hospital Clinico Universitario de Valencia, Valencia Principal Investigator, Dr. Cristina...

2009-06-02 11:43:54

The human body is a mosaic of specialized cells that come together like pieces of a puzzle to create a beating heart, a conscious brain, sensuous nerves and the other tissues and organs. Amidst all of these specialized cells exist stem cells "“ each a blank slate full of potential for developing into pieces of the puzzle that is the human body.Fundamental propertiesAll stem cells have three fundamental properties. They are capable of renewing themselves, are unspecialized and can give...

2009-05-27 07:00:00

Small Molecule Stem Cell Modulator Administered in Dual Cord Blood Transplant for Hematologic Malignancy LA JOLLA, Calif., May 27 /PRNewswire/ -- Fate Therapeutics, Inc. announced today that the first patient has been treated in a Phase 1b clinical trial of FT1050, a small molecule Stem Cell Modulator (SCM) designed to increase hematopoietic stem cell (HSC) number and function through its activation of key pathways that guide cell fate. The study, which is being conducted at the Dana-Farber...

2009-05-13 15:06:51

Blood stem cells literally go with the flow, according to a new report published as an immediate early publication in the journal Cell, a Cell Press journal, on May 13th. Researchers have found that a heart beat and blood circulation are critical signals for the production of blood-forming, or hematopoietic, stem cells in the developing embryo. The evidence found in zebrafish and mice may lead to new methods to coax embryonic stem cell-like cells (known as induced pluripotent stem cells or...

2009-04-09 15:39:05

U.S.-led scientists say they have identified a gene that can protect against leukemia and other blood cancers, possibly paving the way for new therapies. The University of California-San Francisco researchers said they discovered the JunB gene controls the rapid production and differentiation of stem cells that produce all blood cell types. Additionally, the scientists said they uncovered evidence that could lead to a protocol for bone marrow transplants that could boost the chance of a cure...


Word of the Day
omphalos
  • The navel or umbilicus.
  • In Greek archaeology: A central boss, as on a shield, a bowl, etc.
  • A sacred stone in the temple of Apollo at Delphi, believed by the Greeks to mark the 'navel' or exact center-point of the earth.
'Omphalos' comes from the ancient Greek.
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