Latest Hepatic stellate cell Stories
An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, report that significant numbers of myofibroblasts – cells that produce the fibrous scarring in chronic liver injury – revert to an inactive phenotype as the liver heals.
In liver disease, extent of tissue damage depends on the balance between the generation of scar tissue and the regeneration of new liver cells.
UCLA researchers have demonstrated that a key regulator of cholesterol and fat metabolism in the liver also plays an important role in the development of liver fibrosis â€” the build-up of collagen scar tissue that can develop into cirrhosis.
In the latest of a series of related papers, researchers at the University of California, San Diego School of Medicine, with colleagues in Austria and elsewhere, present a new and more definitive explanation of how fibrotic cells form, multiply and eventually destroy the human liver, resulting in cirrhosis.
Curcumin, a chemical that gives curry its zing, holds promise in preventing or treating liver damage from an advanced form of a condition known as fatty liver disease.
Hepatic fibrosis (HF) occurs in most types of chronic liver diseases and approximately 25%-40% of HF cases may ultimately progress to hepatic cirrhosis.
A recent study found that rats with advanced fibrosis that were administered a short-term dose of losartan-M6PHSA had reduced liver inflammation and fibrosis.
A research team from the National Taiwan University Hospital has evaluated the efficiency of transplanted hepatocyte (liver) cells in animal models severely damaged by two kinds of chemical toxicity to see whether and how transplanted hepatocytes were able to efficiently repopulate the toxin-induced, severely damaged livers.
Several studies have shown that lipid peroxidation stimulates collagen production in fibroblasts and hepatic stellate cells (HSC), and plays an important role in the development of liver fibrosis.
In the last decade, advances in the understanding of genes promoting hepatic stellate cell (HSC) activation are impressive.
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