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Latest Hepatocyte Stories

Living Tissues Improved With 3-D printed Vascular Networks Made From Sugar
2012-07-02 08:16:56

Researchers are hopeful that new advances in tissue engineering and regenerative medicine could one day make a replacement liver from a patient's own cells, or animal muscle tissue that could be cut into steaks without ever being inside a cow. Bioengineers can already make 2D structures out of many kinds of tissue, but one of the major roadblocks to making the jump to 3D is keeping the cells within large structures from suffocating; organs have complicated 3D blood vessel networks that are...

2012-03-12 19:45:37

The liver is unique among mammalian organs in its ability to regenerate after significant tissue damage or even partial surgical removal. Laurie DeLeve and her colleagues at the University of Southern California in Los Angeles wanted to better understand which cells are specifically responsible for driving liver regeneration. A specialized cell type, known as liver sinusoidal endothelial cells, has generally been thought to promote regeneration of liver tissue. However, the DeLeve team...

2012-03-05 13:07:00

Scientists have shed light on how the liver repairs itself with research that could help develop drugs to treat liver disease Scientists have shed light on how the liver repairs itself with research that could help develop drugs to treat liver disease. Researchers at the Medical Research Council (MRC) Centre for Regenerative Medicine at the University of Edinburgh have discovered how to enhance the production of key cells needed to repair damaged liver tissue. The study, published in...

2011-05-16 19:37:30

Over-activation of a single gene promotes leukemia, but its loss causes liver cancer An international team of researchers, led by scientists at the University of California, San Diego School of Medicine, and the Eastern Hepatobiliary Surgery Hospital in China, say a human gene implicated in the development of leukemia also acts to prevent cancer of the liver. Writing in the May 17 issue of the journal Cancer Cell, Gen-Sheng Feng, PhD, UCSD professor of pathology, and colleagues in San Diego,...

2011-04-01 16:21:28

Innovation in science This study establishes a unique system to perform in vivo RNAi screens for genetically dissecting the cellular signalling networks that regulate hepatocyte proliferation during chronic liver damage. Functional in vivo validation studies show that stable knockdown of the candidate gene by different shRNAs can significantly increase the repopulation efficiency of mouse hepatocytes and also increase the regenerative capacity of chronically damaged mouse livers. Such...

2011-04-01 16:07:20

Innovation in science Study shows, for the first time, the successful reprogramming of diseased human hepatocytes into induced pluripotent stem cells (iPSC). Results also found differentiation into mature hepatocytes was more efficient than that with fibroblast-derived iPSCs. The generation of diseased hepatocyte-derived human iPSC lines provides a good basis for the study of liver disease pathogenesis. Such technology could give a potentially unlimited reservoir of cells for the treatment of...

2011-01-05 22:41:59

Numerous patients suffering from chronic liver diseases are currently receiving inadequate treatment due to the lack of organs donated for transplantation. However, hepatocytes derived from induced pluripotent stem cells (iPSCs) could offer an alternative for the future. Scientists from the Max Planck Institute for Molecular Genetics in Berlin compared hepatocytes from embryonic stem cells with hepatocytes from iPS cells and found that their gene expression is very similar. Nevertheless, in...

2011-01-04 09:00:00

YOKOHAMA, Japan, January 4, 2011 /PRNewswire/ -- ReproCELL, Inc. (CEO: Chikafumi Yokoyama PhD) announces today that the company will enter a collaborative R&D agreement with the National Institute of Biomedical Innovation (NIBIO; Director General: Koichi Yamanishi; Osaka, Japan), which could offer new hepatocyte derived from human iPS (induced pluripotent stem) cells used for an effective in-vitro drug screening for hepatic toxicity and liver metabolism. ReproCELL is a...


Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.