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Latest Hepatocyte Stories

2009-08-24 16:06:23

Researchers at INSERM (France) have engineered a chimeric protein that increases cell survival, migration and proliferation to improve stem cell engraftment. The results, which appear in the September 2009 issue of Experimental Biology and Medicine, show that TAT-Tpr-Met, a cell permeable form of the hepatocyte growth factor receptor can increase the number of hepatic stem cells integrated into the liver of the mouse. TAT-Tpr-Met is the result of the fusion of Tpr-Met, an autoactived tyrosine...

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2009-06-25 10:05:00

If you have hay fever, headaches or a cold, it's only a short way to the nearest chemist. The drugs, on the other hand, can take eight to ten years to develop. Until now animal experiments have been an essential step, yet they continue to raise ethical issues. "Our artificial organ systems are aimed at offering an alternative to animal experiments," says Professor Heike Mertsching of the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB in Stuttgart. "Particularly as...

2009-06-16 07:00:00

Harness the Dual Benefits of Freshly Isolated Plateability and the Efficiencies of Cryopreservation CHICAGO, June 16 /PRNewswire/ -- In today's competitive environment and economic climate, the financial implications of being the first to file a promising new drug compound or chemical entity cannot be underestimated. Researchers and drug manufacturers are under even greater pressure to do more with less, and productivity and cost savings are at a premium. In the race to succeed, fresh...

2009-04-20 15:25:53

German scientists say they have determined the reason transplanted liver cells don't proliferate as well in older recipients as they do in younger ones. Researchers at Germany's Martin Luther University said they determined that while the age of the donor makes no difference, the age of the recipient is significantly important -- and many humans requiring liver transplantation are older. The German study conducted in rats found that older rats had a repopulation rate of only 2 percent, 10...

2009-04-19 13:13:38

Lower levels of needed growth factor may be the reasonWhen things go right, transplanted healthy liver cells transplanted by infusion or injection will find their way to the liver, integrate into the damaged tissue, start proliferating, and take over the liver's work of helping with digestion and removing waste products and worn-out cells from the blood. Hepatocyte transplantation has been successful in a number of animal models, raising hopes that use of cells could overcome the shortage of...

2009-04-04 10:50:00

A team of researchers from the Massachusetts General Hospital Center for Engineering in Medicine (MGH-CEM) has found the first evidence of cell-to-cell communication by amino acids, the building blocks of proteins, rather than by known protein signaling agents such as growth factors or cytokines. Their report will appear in an upcoming issue of the FASEB Journal and has been released online."We were taken by complete surprise," says Rohit Jindal, PhD, a postdoctoral fellow at MGH-CEM and the...

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2008-03-31 12:15:00

Japanese scientists have designed artificial molecules that reversed liver cirrhosis in rats.Cirrhosis is a hardening or scarring of the liver that occurs when liver cells begin producing collagen, a fibrous material found in skin and tendons.  The researchers said they designed molecules that block collagen production by the liver's "stellate cells," which are also known to absorb vitamin A.  The scientists loaded these molecules into vitamin-A coated carriers, which tricked the...

2005-08-22 14:14:14

A virus that typically infects insects could help with the development of gene therapy treatment for Hemophilia A, a condition in which even a bump on the knee can cause serious internal bleeding in people. Researchers at the University of Iowa Roy J. and Lucille A. Carver College of Medicine improved a vector -- a vehicle that delivers gene therapy to cells -- in two ways to create a sustained, partial correction to bleeding problems in mice engineered to have Hemophilia A, which is also...


Word of the Day
glogg
  • Scandinavian punch made of claret and aquavit with spices and raisins and orange peel and sugar.
This word comes from the Swedish 'glogg,' which is an alteration of 'glodgat,' mulled (wine).
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