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Last updated on April 18, 2014 at 17:24 EDT
Studies Investigate New Less Toxic Treatments For Hepatitis

Studies Investigate New, Less Toxic Treatments For Hepatitis C

redOrbit Staff & Wire Reports - Your Universe Online A new orally-administered antiviral therapy has reportedly cured hepatitis C infection in over 90 percent of patients with liver cirrhosis, according to research published Saturday in the...

Latest Hepatology Stories

2014-04-17 15:40:57

Deaths from viral Hepatitis B and C have surpassed HIV/AIDS in many countries, including Australia and in Western Europe, according to an analysis of the 2010 Global Burden of Disease study. The analysis was conducted by Dr Benjamin Cowie and Ms Jennifer MacLachlan from the University of Melbourne and Melbourne Health, and was presented at The International Liver Congress in London earlier this month. “Liver cancer is the fastest increasing cause of cancer deaths in Australia,...

2014-04-16 09:48:04

Over 20 years after the fatal fialuridine trial, a study published this week in PLOS Medicine demonstrates that mice with humanized livers recapitulate the drug's toxicity. The work suggests that this mouse model should be added to the repertoire of tools used in preclinical screening of drugs for liver toxicity before they are given to human participants in clinical trials. A retrospective analysis by the US National Academy of Sciences of all preclinical fialuridine toxicity tests, which...

2014-04-16 04:21:57

STOCKHOLM, April 16, 2014 /PRNewswire/ -- Wilson Therapeutics, a biopharmaceutical company, today announced that it has closed a $40 million Series B financing co-led by new investors, Abingworth LLP and MVM Life Science Partners LLP ("MVM"). The company's founding investor, HealthCap, also participated in the round. "We are pleased with this significant support from our new as well as existing investors, who represent some of the most experienced in the global life sciences...

2014-04-14 14:09:57

The mechanism which underlies the susceptibility of liver disease patients to life-threatening infection has been uncovered by Wellcome Trust-funded medical scientists, who have also suggested a possible treatment to reverse immune suppression in these patients. Liver disease, or cirrhosis, is currently the fifth leading cause of death in the UK. Cirrhosis patients are more than five times more likely to pick up infections in hospital than patients with other chronic conditions, due to...

2014-04-14 12:32:47

SAN CLEMENTE, Calif., April 14, 2014 /PRNewswire/ -- ROX Medical today announced it has completed enrollment for CONTROL-HTN trial, an international multi center, prospective, randomized, controlled, blinded endpoint trial of the ROX Coupler for the treatment of arterial hypertension. The CONTROL-HTN trial, NCT01642498, is evaluating the safety and efficacy of a percutaneous procedure creating a fixed connection between a central artery and vein in the upper leg - for the treatment...

2014-04-14 12:33:30

Epidemiological, genetic and clinical data presented today at the International Liver CongressTM 2014 are collectively focused on different approaches designed to improve the diagnosis, staging and treatment of hepatocellular carcinoma (HCC). "Human hepatocellular carcinoma is one of the most prevalent cancers worldwide and the second most frequent cause of cancer-related death," said EASL's Scientific Committee Member Dr Helen Reeves Senior Lecturer & Honorary Consultant...

2014-04-14 10:59:02

Results from an international Phase III study presented today at the International Liver CongressTM 2014 have shown obeticholic acid (OCA) given to patients suffering from Primary Biliary Cirrhosis (PBC) who previously had an inadequate response to, or have been unable to tolerate ursodeoxycholic acid (UDCA), produced meaningful biochemical and clinical improvements. UDCA is the only therapy currently approved to treat PBC. Obeticholic acid at both a 10 mg dose and a 5 mg dose titrated to...

2014-04-11 13:01:17

Significant new data presented today at the International Liver Congress™ 2014 indicate that liver cancer (Hepatocellular Carcinoma (HCC)) may be treated by adoptive T-cell therapy. This new therapeutic approach in the treatment of HCC could be very important as without treatment the 5 year survival rate is just 5%. Globally, HCC accounts for 746,000 deaths, and in the UK alone is responsible for over 4,000 deaths per year. Glypican-3 (GPC3) is a tumor associated antigen expressed in...

2014-04-11 12:57:21

New research announced at the International Liver CongressTM 2014 today provides new hope for the notoriously difficult-to-treat population of liver transplant patients with recurring hepatitis C (HCV). As part of a compassionate use program, 104 post-liver transplant patients with recurring HCV who had exhausted all treatment options and had poor clinical prognoses, received sofosbuvir (SOF) and ribavirin (RBV) with pegylated interferon (PEG) included at the physicians’ discretion for...

2014-04-11 00:21:56

LONDON, April 11, 2014 /PRNewswire/ -- - Hepatic encephalopathy (HE) is associated with a significant increase in mortality (58.1% vs. 32.4%), as well as longer hospital stays (8 days vs. 6.8 days) and more primary care visits (18.2 vs. 8.7 contacts per patient year) compared to similar liver patients without HE[i],[ii] - XIFAXAN(R) 550 (rifaximin-alpha) is a cost-effective treatment option for the...


Latest Hepatology Reference Libraries

Chinese Liver Fluke, Clonorchis sinensis
2014-01-12 00:00:00

The Chinese liver fluke (Clonorchis sinensis) is a species of parasitic worm that is classified within the Platyhelminthes phylum. It can be found in Southeast Asia, Taiwan, Japan, and China and is present in nearly 30,000,000 humans today. It is thought to be one of the world’s most pervading parasites. The Chinese liver fluke requires two intermediate, or secondary, hosts and one definitive, or main, host to successfully complete its lifecycle. The first intermediate host is typically...

Southeast Asian Liver Fluke, Opisthorchis viverrini
2014-01-12 00:00:00

The Southeast Asian liver fluke (Opisthorchis viverrini) is a parasite that is classified within the Platyhelminthes phylum. It is native to Vietnam, Cambodia, Thailand, and the Lao People's Democratic Republic. It occurs in higher numbers in northern areas of Thailand when compared to central areas of Thailand, and the disease the worm causes, known as opisthorchiasis, does not occur in southern areas of Thailand. The Southeast Asian liver fluke is so small that it can only be seen under...

Echinococcus multilocularis
2014-01-12 00:00:00

Echinococcus multilocularis is a species of tapeworm that is classified within the Platyhelminthes phylum. It is one of a few worms that cause echinococcosis, a disease that affects many canid species including wolves, coyotes, foxes, jackals, domesticated dogs. Humans can also contract this disease. Adult members of this species can reach an average length of .2 inches, and like other species of tapeworm, its body is segmented by three proglottids. Its head, or scolex, is equipped with...

Liver
2013-04-30 14:18:06

The liver is the organ in charge of processing, neutralizing and excreting certain secretions for the metabolic processes. Formation and Orientation The liver is considered to be both the largest internal organ and the largest gland in the human body. It is situated just below the diaphragm, to the right of the stomach and on top of the gallbladder. There are two ways blood can travel to and from the liver: the hepatic artery and the portal vein. The hepatic artery carries blood solely...

Gallbladder
2013-03-05 14:18:48

The gall bladder is the sac-shaped organ that is the passage between the liver and intestine where bile is held. Formation and Orientation The gall bladder is relatively 8 cm by 4 cm when fully formed. The gallbladder is angled between the rectus abdominis muscle and the costal margin. It is hollow and is made up of three parts; the fundus, the body and the neck. The fundus is the part of the gallbladder that is most far from the cystic duct. This is at the same level of the...

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