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Last updated on April 18, 2014 at 17:24 EDT

Latest HER2/neu Stories

2012-12-05 12:24:16

LOS ANGELES, Dec. 5, 2012 /PRNewswire/ -- Researchers from the Revlon/UCLA Women's Cancer Research Program at UCLA's Jonsson Comprehensive Cancer Center (JCCC) reported an encouraging increase in progression-free survival (PFS, the length of time a patient is on treatment without tumor growth) for patients with breast cancer that was estrogen receptor positive (ER+), HER2-negative who were given a combination of the standard anti-estrogen treatment, letrozole, and a new experimental drug...

2012-12-03 20:57:17

Prostate cancer drug shows promise in triple-negative and estrogen-positive breast cancer Breast cancers are defined by their drivers — estrogen and progesterone receptors (ER and PR) and HER2 are the most common, and there are drugs targeting each. When breast cancer has an unknown driver, it also has fewer treatment options — this aggressive form of breast cancer without ER, PR or HER2, which was thought not to be driven by hormones, is known as triple negative. A decade ago,...

2012-11-27 08:29:17

Research presented at 2012 SABCS examines cardiac safety profile of MM-302, a new HER2-targeted Liposomal Doxorubicin Agent. CAMBRIDGE, Mass., Nov. 27, 2012 /PRNewswire-USNewswire/ -- Merrimack Pharmaceuticals, Inc. (NASDAQ: MACK) today announced that Phase I data evaluating the novel agent MM-302 for the treatment of advanced HER2+ breast cancer and preclinical data on potential imaging and biomarker-based diagnostics will be presented at the 2012 CTRC-AACR San Antonio Breast Cancer...

2012-11-13 08:36:10

WORCESTER, Mass. and TORONTO, Nov. 13, 2012 /PRNewswire/ -- Generex Biotechnology Corporation (OTCBB:GNBT) today provided the following update on company initiatives. Antigen Express, Inc. (www.antigenexpress.com), a wholly-owned subsidiary of Generex, is in late Phase II clinical development of a novel immunotherapeutic for breast cancer (AE37) that demonstrates promising trends in preventing relapse. The interim results of the large, controlled, randomized, and single blinded trial were...

2012-11-02 14:50:28

A University of Cincinnati (UC) cancer biology team reports breakthrough findings about specific cellular mechanisms that may help overcome endocrine (hormone) therapy-resistance in patients with estrogen-positive breast cancers, combating a widespread problem in effective medical management of the disease. Xiaoting Zhang, PhD, and his colleagues have identified a specific estrogen receptor co-activator–known as MED1–as playing a central role in mediating tamoxifen resistance...

2012-10-16 07:27:07

SAN ANTONIO, Oct. 16, 2012 /PRNewswire/ -- If Col. George Peoples has anything to say about it, pink ribbons will one day be obsolete and breast cancer will be a preventable disease. Peoples, chief of surgical oncology at San Antonio Military Medical Center (SAMMC) is the founder, director and principal investigator of the Cancer Vaccine Development Program (CVDP), an Army research network that this month is celebrating a few milestones toward its mission to prevent breast cancer. Breast...

2012-10-08 13:27:11

The HIV protease inhibitor, Nelfinavir, can be used to treat HER2-positive breast cancer in the same capacity and dosage regimen that it is used to treat HIV, according to a study published October 5 in the Journal of the National Cancer Institute. Breast cancer is one of the most common causes of cancer deaths in the U.S. with approximately 39,520 women succumbing to the disease in 2011. HER2-postive breast cancer is known to be more aggressive and less responsive to treatments compared...

2012-10-02 02:30:25

CAMBRIDGE, Mass., Oct. 2, 2012 /PRNewswire/ -- Merrimack Pharmaceuticals, Inc. (NASDAQ: MACK) today announced the presentation of Phase 1 safety and clinical results evaluating two potential new therapies with a novel target - ErbB3, a signaling receptor believed to be responsible for triggering tumor growth and resistance in a number of malignancies including breast, ovarian, gastric, esophageal and bladder cancers. The two studies were presented in poster sessions at the European Society...

2012-10-01 16:32:24

Human epidermal growth factor (HER2) positive breast cancers are often treated with the same therapy regardless of hormone receptor status. New research published in BioMed Central's open access journal Breast Cancer Research shows that women whose HER2 positive cancer was also hormone (estrogen and progesterone) receptor (HR) negative had an increased risk of early death, and that their cancer was less likely to recur in bone than those whose cancer retained hormone sensitivity. Breast...

2012-09-19 15:50:04

The Vall d'Hebron Breast Cancer Unit, the Vall d'Hebron Institute of Oncology (VHIO) and SOLTI, an academic breast cancer research group are heading up a multi-center international study involving four Spanish and three North American research centers. The aim of the study is to investigate whether BKM120, a drug that inhibits the PI3K pathway (phosphatidylinositol-3-Kinase) can be an effective treatment against triple-negative breast cancer. At present it is known that breast cancer can...