Latest Herpes simplex virus Stories

Children's Hospital of Philadelphia researcher finds hints of broader viral strategy in cell defense manipulations New biological research reveals how an invading virus hijacks a cell's workings by imitating a signaling marker to defeat the body's defenses. By manipulating cell signals, the virus destroys a defensive protein designed to inhibit it. This finding, from studies in human cell cultures, may represent a broader targeting strategy used by other viruses, and may lay the scientific...

-- Children's Hospital of Philadelphia Researcher Finds Hints of Broader Viral Strategy in Cell Defense Manipulations-- PHILADELPHIA, March 26, 2012 /PRNewswire-USNewswire/ -- New biological research reveals how an invading virus hijacks a cell's workings by imitating a signaling marker to defeat the body's defenses. By manipulating cell signals, the virus destroys a defensive protein designed to inhibit it. This finding, from studies in human cell cultures, may represent a broader...

For the first time, researchers have developed a 3D picture of a herpes virus protein interacting with a key part of the human cellular machinery, enhancing our understanding of how it hijacks human cells to spread infection and opening up new possibilities for stepping in to prevent or treat infection. This discovery uncovers one of the many tactical manoeuvres employed by the virus.The Biotechnology and Biological Sciences Research Council (BBSRC)-funded team, led by The University of...

RESEARCH TRIANGLE PARK, N.C., Jan. 7, 2011 /PRNewswire/ -- Chimerix, Inc., a pharmaceutical company developing orally-available antiviral therapeutics, today announced that patient enrollment has begun in a multicenter, open-label clinical study of CMX001 (the CMX001-350 study) for the treatment of life-threatening or serious conditions caused by double-stranded DNA (dsDNA) viruses. Under the expanded-access protocol developed in conjunction with the U.S. Food and Drug Administration...

Virologists surprised to discover that a common herpesvirus hidden in chromosomes of some people can be reactivated to infectious formTampa, FL -- Human herpesvirus 6 (HHV-6) infects nearly 100 percent of humans in early childhood, and the infection then lasts for the rest of a person's life. Now, a team led by Peter Medveczky, MD, a professor in the Department of Molecular Medicine at the University of South Florida (USF), has discovered that in some individuals, HHV-6 causes such a...

A viral infection is like an uninvited, tenacious houseguest in the cell, using a range of tricks to prevent its eviction. Researchers at the Salk Institute for Biological Studies have identified one of the key proteins allowing herpes simplex virus (HSV) DNA to fly under the radar of their hosts' involuntary hospitality.Their findings, to be published in a forthcoming issue of The EMBO Journal, reveal one of the tactics that HSV employs in order to overcome its hosts' defenses and may...

Condom use is associated with a 30 percent reduced risk of contracting herpes simplex virus 2, also known as genital herpes, U.S. researchers said. Emily T. Martin of Children's Hospital Research Institute and the University of Washington in Seattle and colleagues analyzed data from six studies to assess the effectiveness of condom use in preventing genital herpes. The studies included 5,384 Herpes simplex virus 2-negative individuals -- average age 29 -- at baseline for a combined total...

By Shishido-Hara, Yukiko Higuchi, Kayoko; Ohara, Sinji; Duyckaerts, Charles; Hauw, Jean-Jacques; Uchihara, Toshiki Abstract Progressive multifocal leukoencephalopathy is a fatal demyelinating disorder due to human polyomavirus JC infection in which there are viral inclusions in enlarged nuclei of infected oligodendrocytes. We report that the pathogenesis of this disease is associated with distinct subnuclear structures known as promyelocytic leukemia nuclear bodies (PML-NBs). Postmortem...

Findings may be good news for millions suffering from herpesSALT LAKE CITY "“ There's a high probability that people who are prone to herpes simplex virus (HSV) outbreaks can inherit that susceptibility through their genes, University of Utah researchers report in a new study.In the Feb. 1 issue of The Journal of Infectious Diseases, the researchers identify a region on the long arm of human chromosome 21 with high odds"”at least 1,000-to-1"”of being linked to cold sore susceptibility....