Latest Herpesviridae Stories
polyDNA answers new questions on herpes, HSV, herpes virus, genital sores, etc. collected from the public in its March, 2013 survey. Rochester, NY (PRWEB) March 13, 2013 Genital herpes can spread from one area in the body to another via touching active lesions, as well as through oral sex. One survey respondent commented, “I mean I don’t know…can herpes really travel from one spot on your genitals to say, your legs or someplace else on your body? Sometimes I get sores and they’re...
In a paper published by Cell Host and Microbe on Feb. 13, a research team led by Blossom Damania, PhD, of the Department of Microbiology and Immunology and member of the UNC Lineberger Comprehensive Cancer Center, found that suppressing the TLK enzyme causes the activation of the lytic cycle of both EBV and KSHV. During this active phase, these viruses begin to spread and replicate, and become vulnerable to anti-viral treatments. “When TLK is present, these viruses stay latent, but when...
A genetically reprogrammed Herpes simplex virus (HSV) can cure metastatic diffusion of human cancer cells in the abdomen of laboratory mice, according to a new study published January 31 in the Open Access journal PLOS Pathogens. The paper reports on the collaborative research from scientists at the at the University of Bologna and specifically describes that the HSV converted into a therapeutic anticancer agent attacks breast and ovarian cancer metastases. Past decades have witnessed...
Max-Planck-Gesellschaft The genome encodes the complete information needed by an organism, including that required for protein production. Viruses, which are up to a thousand times smaller than human cells, have considerably smaller genomes. Using a type of herpesvirus as a model system, the scientists of the Max Planck Institute of Biochemistry in Martinsried near Munich and their collaboration partners at the University of California in San Francisco have shown that the genome of this...
New research suggests that just one or two individual herpes virus particles attack a skin cell in the first stage of an outbreak, resulting in a bottleneck in which the infection may be vulnerable to medical treatment. Unlike most viruses that spread to new cells by bombarding them with millions of particles, herpes simplex virus type 1 (HSV-1) — a virus that causes cold sores and genital lesions — requires just one or two viral particles to infect a skin cell in the first stage of...
An important breakthrough by IRCM researchers contributes to a better understanding of the human genome Researchers at the IRCM, led by geneticist Dr. Jacques Drouin, recently defined the interaction between two essential proteins that control inflammation. This important breakthrough will be published in tomorrow's print edition of the scientific journal Molecular Cell. IRCM scientists study glucocorticoids, a class of steroid hormones that suppress the immune system and reduce...
One-third of febrile seizures associated with roseola virus New research shows that human herpesviruses (HHV)-6B and HHV-7, commonly know as roseola virus), account for one third of febrile status epilepticus (FSE) cases. Results of the FEBSTAT prospective study now available in Epilepsia, a journal published by Wiley-Blackwell on behalf of the International League Against Epilepsy (ILAE), suggest that HHV-6B may be involved in the development of epilepsy and further research is urgently...
Results of a systematic review urge prophylactic treatment for those at risk Patients with inflammatory rheumatic diseases (IRD) treated with anti-tumor necrosis factor medications (anti-TNFs) have a 75% greater risk of developing herpes zoster, or shingles, than patients treated with traditional disease modifying anti-rheumatic drugs (DMARDs), according to a meta-analysis presented today at EULAR 2012, the Annual Congress of the European League Against Rheumatism. "Anti-TNFs, such as...
A team of researchers, including a scientist from the Viral Immunology Center at Georgia State University, have found that a type of herpesvirus infection of the eye is associated with neovascular age-related macular degeneration (AMD), a disease that causes blindness in the elderly. The scientists found that human cytomegalovirus, a type of herpesvirus, causes the production of vascular endothelial growth factor, or VEGF, a signal protein that regulates the formation of new blood vessels....
Kaposi's sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi's sarcoma and primary effusion lymphoma (PEL). PELs are aggressive lymphomas with reported median survival time shorter than six months after diagnosis. Researchers at the University of Helsinki discovered that spontaneous induction of KSHV lytic replication in tumors drastically attenuated the p53-dependent apoptotic response not only to a targeted therapy (Nutlin-3) but also to genotoxic...
Latest Herpesviridae Reference Libraries
The Herpesviridae, a large family of DNA viruses, causes disease in animals and humans. Members of this family are known as herpesviruses. They all share a common structure where they are composed of relatively large double-stranded, linear DNA genomes encoding 100-200 genes encased within an icosahedral protein cage called the capsid. The whole particle is known as a virion. They are all nuclear-replicating. When a viral particle contacts a cell with specific types of receptor molecules...
Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), are two members of the virus family Herpesviridae that infect humans. They are both ubiquitous and contagious and can spread when an infected person is producing and shedding the virus. Symptoms include watery blisters in the skin, mouth, lips, or genitals. Lesions usually heal with a scab characteristic of herpetic disease. HSV-1 and -2 remain latent in the body hiding from the immune system in the cell bodies of nerves. Some people do...
Feline viral rhinotracheitis (FVR), caused by feline herpesvirus 1, is an upper respiratory infection of cats. It can also be referred to as feline influenza or feline coryza. FVR causes one-half of respiratory disease in cats. Feline calicivirus is another of the most common diseases to cause respiratory infection in cats. It is very contagious and can cause major problems including death from pneumonia in young kittens. It is transmitted only through direct contact. It reproduces in the...
