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Latest Histone deacetylase Stories

2011-04-26 05:00:00

SUNNYVALE, Calif., April 26, 2011 /PRNewswire/ -- Pharmacyclics, Inc. (Nasdaq: PCYC) announced today that it has received a $7 million milestone payment for its histone deacetylase (HDAC) inhibitor, PCI-24781 / S 78454 from Les Laboratoires Servier ("Servier") based on an ex-US collaboration agreement signed in April of 2009. Over the past two years Servier has engaged in several exploratory Phase I/II trials in solid tumors and hematologic malignancies. Servier is now focused on its...

2011-04-15 00:00:28

BellBrook Labs has developed a new HTS assay for screening methyltransferases, the family of enzymes involved in epigenetic modifications that cause cancerous cell growth and metastasis. The innovative EPIGEN Methyltransferase Assay combines proprietary coupling enzymes with the detection module of the extensively validated Transcreener® HTS Assay platform to advance the discovery of new anti-cancer therapeutics. Madison, WI (PRWEB) April 14, 2011 BellBrook Labs today introduced an...

2011-04-05 14:53:42

Tumor suppressor genes normally control the growth of cells, but cancer can spring up when these genes are silenced by certain chemical reactions that modify chromosomes. Among the most common culprits responsible for inactivating these genes are histone deacetylases, a class of enzymes that remove acetyl groups from DNA-scaffolding proteins, and DNA methyltransferases, a family of enzymes that add methyl groups to DNA. Drugs that counteract these enzymes, and thus reactivate tumor suppressor...

2011-04-04 08:06:28

(Ivanhoe Newswire) -- Scientists have achieved one of the oldest and most rarely achieved goals of cancer research"”they have found a way to "distract" cancer cells from their normal activities and make them act like normal cells. The scientists, from Dana-Farber Cancer Institute and Brigham and Women's Hospital, managed to distract the cancer cells of a rare form of cancer called NUT midline carcinoma (NMC) that usually affects children and young adults. NMC is lethal; according to...

2011-03-31 07:30:00

WALTHAM, Mass., March 31, 2011 /PRNewswire/ -- Syndax Pharmaceuticals, Inc., a clinical-stage epigenetics oncology company, today announced 11 posters on entinostat, an oral, highly selective, class I histone deacetylase (HDAC) inhibitor, will be presented at the 102nd Annual American Association for Cancer Research meeting April 2 to April 6 in Orlando, FL. "The breadth of exciting data being presented at AACR provides additional insight into the opportunities for Syndax to build out...

2011-03-22 00:25:45

A paper announcing a breakthrough discovery in the fight against Niemann-Pick Type C, coauthored by Olaf Wiest and Paul Helquist of the University of Notre Dame's Department Chemistry & Biochemistry and Frederick Maxfield, Chair of Biochemistry at Cornell University Weill College of Medicine, appears in the Proceedings of the National Academy of Sciences this week. The paper shows how use of a histone deacetylase inhibitor correct the damage done by the genetic disorder and allowed...

2011-03-10 23:17:56

The liver normally makes and stores fat, which is required in moderation for normal body function. However, if the process goes awry, excess fat in the liver can cause major liver damage. In fact, fatty liver is a leading cause of liver failure in the United States, and is often brought on by obesity and diabetes. In turn, the increasing prevalence of these diseases has brought with it an epidemic of liver disease. Abnormal sleep patterns, such as those of shift-workers, can be risk factors...

2011-02-02 13:23:39

One of Mother Nature's latest gifts to medical science is stirring excitement with the discovery that the substance "” obtained from a coral-reef inhabiting cyanobacterium "” appears to be an ideal blueprint for developing new drugs for serious fractures, osteoporosis, and other bone diseases. That's the conclusion of a study on the substance, Largazole, in the journal ACS Medicinal Chemistry Letters. By some estimates, more than half of today's medications are in Largazole's...

2011-01-26 17:33:08

A new study provides insight into how stress impacts the brain and may help to explain why some individuals are predisposed to depression when they experience chronic stress. The research, published by Cell Press in the January 27 issue of the journal Neuron, reveals complex molecular mechanisms associated with chronic stress and may help to guide new treatment strategies for depression. "Many individuals exposed to stressful events do not show signs or symptoms of depression; however, some...

2011-01-20 06:00:00

WALTHAM, Mass., Jan. 20, 2011 /PRNewswire/ -- Repligen Corporation (Nasdaq: RGEN) announced today that it has entered into an exclusive license agreement with the University of California, Irvine (UCI) for a patent application covering the use of histone deacetylase 3 (HDAC3) inhibitors for the treatment of disorders involving preservation or extinction of memory including Alzheimer's disease, memory impairment and post traumatic stress disorder. The patent application is based on work...


Word of the Day
caparison
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.
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