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Latest Histone deacetylase Stories

2010-07-27 08:00:00

WHITE PLAINS, N.Y. and CAMBRIDGE, Mass., July 27 /PRNewswire/ -- The Leukemia & Lymphoma Society (LLS) and Shape Pharmaceuticals announced today that they have entered into a partnership to advance Shape's novel, topical treatment for cutaneous T-Cell lymphoma (CTCL) into clinical development. The compound, SHP-141, is a first-in-class topical histone deacetylase inhibitor with the potential to treat both early- and late-stage CTCL. Through the partnership, LLS will provide funding of...

2010-05-24 07:00:00

WALTHAM, Mass., May 24 /PRNewswire/ -- Syndax Pharmaceuticals, Inc., a clinical-stage epigenetics company, announced today that abstracts related to its lead anti-cancer compound, entinostat, an orally bioavailable, selective, class I histone deacetylase (HDAC) inhibitor, will be presented at the 46th American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, IL. "The data and information we are presenting at the Annual ASCO Meeting support entinostat's promise in combination...

2010-05-09 07:59:59

The world's scientific community may be one step closer to understanding age-related memory loss, and to developing a drug that might help boost memory. In an editorial published May 7 in Science, J. David Sweatt, Ph.D., chair of the University of Alabama at Birmingham (UAB) Department of Neurobiology, says that drugs known as histone deacetylase inhibitors are showing great promise in stopping memory loss "“ and even in boosting the formation of memory in animal models. Sweatt's...

2010-04-28 15:07:13

In studies on cancer, heart disease, neurological disorders and other degenerative conditions, some scientists are moving away from the "nature-versus-nurture" debate and are finding you're not a creature of either genetics or environment, but both "“ with enormous implications for a new approach to health. The new field of "epigenetics" is rapidly revealing how people, plants and animals do start with a certain genetic code at conception. But the choice of which genes are "expressed,"...

2010-04-15 16:10:00

SUNNYVALE, Calif., April 15 /PRNewswire-FirstCall/ -- Pharmacyclics, Inc. (Nasdaq: PCYC) today announced multiple presentations covering its Btk and HDAC programs at the American Association for Cancer Research (AACR) 2010 Annual Meeting being held April 17-21 in Washington, DC. The oral presentation describes efficacy of the company's first-in-human Btk inhibitor PCI-32765 in a mouse model of pancreatic cancer (Soucek et al). Two other presentations describe the discovery of drug...

2010-03-10 03:00:00

Collaboration Exploits Cellzome's World-Leading Proteomics Technology in Epigenetics CAMBRIDGE, England and HEIDELBERG, Germany, March 10, 2010 /PRNewswire/ -- Cellzome today announced that it has formed a second strategic alliance with GlaxoSmithKline (GSK). This new collaboration gives GSK exclusive access to Cellzome's proprietary Episphere(TM) technology in the emerging field of epigenetics as applied to immunoinflammatory disease. Epigenetic mechanisms play a key role in...

2010-02-23 10:14:00

CAMBRIDGE, England, February 23, 2010 /PRNewswire/ -- From its broad portfolio of novel targets in epigenetics, CellCentric has out-licensed exclusively the development and commercialisation of an important programme focused on cancer. Under the terms of the new agreement, CellCentric will receive from Takeda Pharmaceutical Company Limited an upfront payment and pre-clinical and clinical milestones, in addition to royalties. Based on the royalties and milestones defined, the overall...

2009-11-05 06:00:00

WALTHAM, Mass., Nov. 5 /PRNewswire-FirstCall/ -- Repligen Corporation (Nasdaq: RGEN) today reported results for the second quarter of fiscal year 2010, ended September 30, 2009. Total revenue for the quarter was $5,421,000 compared to total revenue of $5,090,000 for the second quarter of fiscal year 2009 ended September 30, 2008. Total revenue for the second quarter of fiscal year 2010 was comprised of Protein A product revenue of $2,742,000 and royalty and research revenue of $2,679,000,...

2009-09-26 08:58:00

Discovery takes researchers 1 step closer to human clinical trials and could improve understanding of other diseases Using clever chemistry, a Scripps Research team has pinpointed the enzyme target of a drug group that stops the progression of the devastating disease Friedreich's ataxia in mice and may do the same for humans. The findings, developed in collaboration with scientists from Repligen Corporation, help advance this treatment approach one step closer toward human clinical trials,...

2009-09-25 11:15:00

WALTHAM, Mass., Sept. 25 /PRNewswire-FirstCall/ -- Repligen Corporation (Nasdaq: RGEN) reported today publication of research that identifies histone deacetylase 3 (HDAC 3) as an important enzyme target for therapeutic intervention in Friedreich's ataxia. These research findings confirm the drug target of the HDAC inhibitors that Repligen is currently developing for the treatment of inherited neurodegenerative diseases such as Friedreich's ataxia. The study entitled "Chemical Probes...


Word of the Day
caparison
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.
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