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Latest Histone deacetylase Stories

2008-09-16 12:00:10

WALTHAM, Mass., Sept. 16 /PRNewswire-FirstCall/ -- Repligen Corporation today reported publication of a preclinical study demonstrating that a novel histone deacetylase (HDAC) inhibitor improved disease symptoms in a transgenic animal model of Huntington's disease. The study, led by scientists at The Scripps Research Institute, demonstrated that oral administration of the drug candidate to the mice after the onset of symptoms slowed the progression of disease. Treated animals showed...

2008-08-21 09:15:00

U.S. chemists synthesize promising anti-cancer product WASHINGTON, Aug. 20 (Xinhua) -- Duke University announced on Wednesday that its chemists have patented an efficient technique for synthesizing a marine algae extract in sufficient quantities to now test its ability to inhibit the growth of cancerous cells. The researchers also deduced that this molecule, called largazole, acts on cells through the same chemical mechanism as other anti-cancer compounds on the market or in clinical trials....

2008-08-08 12:00:45

U.S. scientists say they've found a marine compound that inhibits cancer cell growth in lab tests and that might lead to new anti-cancer drugs. University of Florida College of Pharmacy researchers said the patented compound, called largazole, is derived from cyanobacteria that grow on coral reefs. "It's exciting because we've found a compound in nature that may one day surpass a currently marketed drug or could become the structural template for rationally designed drugs with improved...

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2008-07-10 12:00:00

Researchers at The Children's Hospital of Philadelphia have manipulated cell activity that occurs during the interruption of blood flow to strongly protect heart tissue in animal studies. The finding has the potential to become an emergency treatment for heart attack patients, particularly since already existing drugs might be pressed into service to produce the protective effects. "Reduced blood flow, or ischemia, is a major problem in many organs, where it can lead to cell death and tissue...

2008-06-26 06:01:52

ValiRx plc (AIM:VAL, 'ValiRx'), the cancer therapeutics and diagnostics company, has announced promising in vivo results for its lead molecule VAL 101 which uses its gene silencing technology GeneICE(TM) in preclinical xenograph models of pancreatic cancer. Studies showed that the tumour growth was less than half the size of that seen in the control group. Based on these results, the Company will now initiate further preclinical studies with the aim of progressing VAL 101 toward...

2008-06-18 12:00:59

Gloucester Pharmaceuticals has reported positive data from a Phase II trial of romidepsin, a novel, cyclic peptide, pan-HDAC inhibitor under investigation for hematologic malignancies. The study conducted by the US National Cancer Institute is a seven-arm, Phase II, open-label trial of romidepsin in patients with cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma (PTCL). The study enrolled 71 CTCL patients in three arms of the study that received romidepsin. Patients received...

2008-06-17 09:00:08

Gloucester Pharmaceuticals today announced that positive data from a Phase 2 trial of romidepsin conducted by the U.S. National Cancer Institute (NCI) were presented at the 13th Congress of the European Hematology Association in Copenhagen, Denmark. Romidepsin is a novel, cyclic peptide, pan-HDAC inhibitor under investigation for hematologic malignancies. In a presentation entitled Romidepsin Induces Clinically Significant and Durable Responses in Relapsed or Refractory CTCL: A National...

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2008-05-19 09:45:00

An herb used in traditional medicine by many Middle Eastern countries may help in the fight against pancreatic cancer, one of the most difficult cancers to treat. Researchers at the Kimmel Cancer at Jefferson in Philadelphia have found that thymoquinone, an extract of nigella sativa seed oil, blocked pancreatic cancer cell growth and killed the cells by enhancing the process of programmed cell death.While the studies are in the early stages, the findings suggest that thymoquinone could...

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2008-04-02 11:38:25

Reshaping of the DNA scaffolding that supports and controls the expression of genes in the brain may play a major role in the alcohol withdrawal symptoms, particularly anxiety, that make it so difficult for alcoholics to stop using alcohol.The finding is reported by researchers at the University of Illinois at Chicago and the Jesse Brown VA Medical Center in the April 2 issue of the Journal of Neuroscience.DNA can undergo changes in function without any changes in inheritance or coded...

2007-06-20 21:03:48

SINGAPORE, June 20 /PRNewswire/ -- S*BIO Pte Ltd announced today that it has become Singapore's first biotechnology company to initiate a Phase I clinical trial of a novel anti-cancer compound. The compound, SB939, belongs to a new class of targeted anti-cancer therapeutics called histone deacetylase (HDAC) inhibitors. SB939 is designed to be a "best-in-class" therapeutic amongst HDAC inhibitors being developed worldwide, and has demonstrated the potential to bring additional therapeutic...


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.