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Latest Histone H3 Stories

2013-08-12 14:03:29

Stowers investigators show that rules governing expression of developmental genes in mouse embryonic stem cells are more nuanced than anticipated A decade ago, gene expression seemed so straightforward: genes were either switched on or off. Not both. Then in 2006, a blockbuster finding reported that developmentally regulated genes in mouse embryonic stem cells can have marks associated with both active and repressed genes, and that such genes, which were referred to as "bivalently marked...

2013-04-02 10:30:31

Most cancer treatments are blunt. In an attempt to eradicate tumors, oncologists often turn to radiation or chemotherapy, which can damage healthy tissue along with the cancerous growths. New research from C. David Allis' laboratory at Rockefeller University may bring scientists closer to designing cancer therapeutics that can target tumors with pinpoint accuracy. Their findings, published last week in Science Express, follow a recent series of discoveries by several international genome...

2012-10-01 16:28:13

Over the last two decades, scientists have come to understand that the genetic code held within DNA represents only part of the blueprint of life. The rest comes from specific patterns of chemical tags that overlay the DNA structure, determining how tightly the DNA is packaged and how accessible certain genes are to be switched on or off. As researchers have uncovered more and more of these "epigenetic" tags, they have begun to wonder how they are all connected. Now, research from the...

2012-08-14 12:02:29

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have discovered a mechanism that explains how some cancer cells “hijack” a biological process to potentially activate cell growth and the survival of cancer gene expression. Their study appeared in a recent issue of Nature Structural & Molecular Biology. The newly discovered mechanism involves histones (highly alkaline proteins found in cells that package and order DNA), and in this...

2012-05-01 09:42:57

A team of Stowers scientists defines biochemical crosstalk between DNA interacting proteins and their modifications When stretched out, the genome of a single human cell can reach six feet. To package it all into a tiny nucleus, the DNA strand is tightly wrapped around a core of histone proteins in repeating units–each unit known as a nucleosome. To allow access for the gene expression machinery the nucleosomes must open up and regroup when the process is complete. In the May 1,...

2012-03-14 13:56:38

A team of researchers led by scientists at The Rockefeller University has identified a novel mechanism by which influenza interferes with antiviral host response. The finding, reported in this week's issue of the journal Nature, shows that the immunosuppressive NS1 protein of the influenza A virus hijacks key regulators of antiviral gene function by mimicking a core component of gene regulating machinery. The results they describe have major implications for our understanding of the biology...

2012-03-02 01:17:19

Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, they have determined the 3-D structure and interactions of the histone chaperone Rtt106 down to the atomic details. "The interactions we described are important for gene silencing and the DNA damage response," says senior author Georges Mer, Ph.D., a Mayo Clinic structural...

2012-01-30 08:24:04

Washington University Pediatric Cancer Genome Project provides first evidence linking cancer to mutations in genes involved in DNA organization Researchers studying a rare, lethal childhood tumor of the brainstem discovered that nearly 80 percent of the tumors have mutations in genes not previously tied to cancer. Early evidence suggests the alterations play a unique role in other aggressive pediatric brain tumors as well. The findings from the St. Jude Children's Research Hospital...

2012-01-27 08:00:00

Oryzon a Biopharmaceutical company dedicated to the discovery of biomarkers and development of novel therapeutics and diagnostics announced today that Dr. Tamara Maes, will present at the 4th Annual CHI X-Gen Congress, in the CLINICAL GENOMICS. Epigenetics, Targets and Therapies: on March 5-7 March at the Hilton San Diego Resort in San Diego, California Barcelona, Spain (PRWEB) January 27, 2012 Dr. Maes's presentation will occur on March 6th at 11:00 am. Under the title “Development...

2011-01-21 14:28:57

Acetylation complex fits like a halo over a histone To understand the emerging science of epigenetics"”a field that describes how genes may be regulated without altering the underlying DNA itself"”scientists are deciphering the many ways in which enzymes act on the proteins surrounding DNA within cells. One type of these enzymes, proteins known as histone acetyltransferases (HATs), act on DNA by modifying DNA-bound proteins called histones. This act of modification, called...


Word of the Day
monteith
  • A large punch-bowl of the eighteenth century, usually of silver and with a movable rim, and decorated with flutings and a scalloped edge. It was also used for cooling and carrying wine-glasses.
  • A kind of cotton handkerchief having white spots on a colored ground, the spots being produced by a chemical which discharges the color.
This word is possibly named after Monteith (Monteigh), 'an eccentric 17th-century Scotsman who wore a cloak scalloped at the hem.'
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