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Latest Histone Stories

2014-06-23 08:27:29

First revenues from VolitionRx Nucleosomics technology NAMUR, Belgium, June 23, 2014 /PRNewswire/ -- VolitionRx Limited (OTCQB: VNRX), a life sciences company, today announces its first wholesale order of NuQ® Research Use Only kits to Active Motif. Each kit allows epigenetics researchers to identify and analyze a different nucleosome structure. Active Motif will distribute the kits in its key markets of Europe, the United States and Japan. These assays allow researchers -- in areas as...

Male Fertility Relies On A Key Protein That Also Protects Against Disease
2014-05-13 10:58:14

Brett Smith for redOrbit.com - Your Universe Online Male infertility prevents many couples from being able to conceive a child and a new study published in the journal Nature Communications has found a specific protein that is a major determining factor in determining a sperm’s ability to fertilize an egg. The protein, known as Chd5, is responsible for effectively packaging DNA inside the head of a sperm, where space it at a premium. Each cell in the body contains an entire copy of...

2014-04-01 15:23:26

New research in The FASEB Journal suggests that molecular function of the "hairless" gene may explain why mutations contribute to the pathogenesis of atrichia with papular lesions, a rare form of hair loss It's not a hair-brained idea: A new research report appearing in the April 2014 issue of The FASEB Journal explains why people with a rare balding condition called "atrichia with papular lesions" lose their hair, and it identifies a strategy for reversing this hair loss. Specifically the...

Delivery Of Genomic Building Blocks Controlled By Enzyme
2014-03-07 10:14:25

University of Copenhagen Our DNA and its architecture are duplicated every time our cells divide. Histone proteins are key building blocks of this architecture and contain crucial information that regulates our genes. Danish researchers show how an enzyme controls reliable and high-speed delivery of histones to DNA copying hubs in our cells. This shuttling mechanism is crucial to maintain normal function of our genes and prevent disease. The results are published in the journal Nature...

2014-02-25 13:58:56

Technological discovery Cells in our body are constantly dividing to maintain our body functions. At each division, our DNA code and a whole machinery of supporting components has to be faithfully duplicated to maintain the cell’s memory of its own identity. Researchers at BRIC, University of Copenhagen, have developed a new technology that has revealed the dynamic events of this duplication process and the secrets of cellular memory. The results are published in Nature Cell Biology....

2014-02-10 11:03:42

A Lawrence Livermore National Laboratory physicist and his colleagues have found a new application for the tools and mathematics typically used in physics to help solve problems in biology. Specifically, the team used statistical mechanics and mathematical modeling to shed light on something known as epigenetic memory -- how an organism can create a biological memory of some variable condition, such as quality of nutrition or temperature. "The work highlights the interdisciplinary...

2014-01-16 14:30:04

Application of global sequencing technology reveals how an activator of gene expression stays focused At a glance, DNA is a rather simple sequence of A, G, C, T bases, but once it is packaged by histone proteins into an amalgam called chromatin, a more complex picture emerges. Histones, which come in four subtypes—H2A, H2B, H3, and H4—can either coil DNA into inaccessible silent regions or untwist it to allow gene expression. To further complicate things, small chemical flags, such as...

Physical Reason For Shape Of Metaphase Chromosome Discovered
2014-01-15 07:37:00

Universitat Autonoma de Barcelona This work gives a solution to a fundamental question in structural biology: Why do metaphase chromosomes have their characteristic elongated cylindrical shape? The proposed solution is consistent with the structure of metaphase chromatin and with the nanomechanical properties of chromatin and chromosomes. It is a research at the interface between biology (higher order chromatin structure) and physical sciences (supramolecular structures and nanomaterials)....

2013-08-12 14:03:29

Stowers investigators show that rules governing expression of developmental genes in mouse embryonic stem cells are more nuanced than anticipated A decade ago, gene expression seemed so straightforward: genes were either switched on or off. Not both. Then in 2006, a blockbuster finding reported that developmentally regulated genes in mouse embryonic stem cells can have marks associated with both active and repressed genes, and that such genes, which were referred to as "bivalently marked...

2013-07-23 13:31:35

New technique can rapidly turn genes on and off, helping scientists better understand their function. Although human cells have an estimated 20,000 genes, only a fraction of those are turned on at any given time, depending on the cell’s needs — which can change by the minute or hour. To find out what those genes are doing, researchers need tools that can manipulate their status on similarly short timescales. That is now possible, thanks to a new...


Word of the Day
cenobite
  • One of a religious order living in a convent or in community; a monk: opposed to anchoret or hermit (one who lives in solitude).
  • A social bee.
This word comes from the Latin 'coenobium,' convent, which comes from the Greek 'koinobios,' living in community.
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