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Latest Histone Stories

5c1c4cc2d7878e7634dc4980aabc86391
2009-02-13 10:31:27

Linker histone H1 is important for chromosome structure and gene regulation Scientists at Albert Einstein College of Medicine of Yeshiva University have found that a class of chromatin proteins is crucial for maintaining the structure and function of chromosomes and the normal development of eukaryotic organisms. The research, reported in yesterday's print issue of Genes and Development, also found that this protein class, known as linker histones, works to regulate gene expression in vivo....

2009-02-05 10:16:48

Scientists at the University of North Carolina at Chapel Hill School of Medicine have discovered a gene that when mutated causes obesity by dampening the body's ability to burn energy while leaving appetite unaffected.The new research could potentially lead to new pharmacologic approaches to treating obesity in humans that do not target the brain, according to study senior author Yi Zhang, Ph.D., Howard Hughes Medical Institute investigator and professor of biochemistry and biophysics in the...

7e84fc9f78262c4c11d7c39e549dcbba1
2009-01-29 11:22:34

Anyone who has ever battled a stuck zipper knows it's a good idea to see what's stuck, where and how badly -- and then to pull hard. A Cornell research team's experiments involve the "unzipping" of single DNA molecules. By mapping the hiccups, stoppages and forces along the way, they have gained new insight into how genes are packed and expressed within cells. The research, published online Jan. 11 in Nature Structural and Molecular Biology (doi: 10.1038/nsmb.1526), was led by Michelle Wang,...

fd6a9260c4c8931884630e191a78dd771
2009-01-18 14:59:33

Epigenetic finding adds insight on how cells become brain, liver -- and malignant Experiments at Johns Hopkins have found that the gradual maturing of embryonic cells into cells as varied as brain, liver and immune system cells is apparently due to the shut off of several genes at once rather than in individual smatterings as previous studies have implied. Working with mouse brain and liver cells, as well as embryonic stem cells, Johns Hopkins University School of Medicine professor Andrew...

2008-12-15 09:59:31

Eric Selker's lab reports progress on biochemical communications among proteins involved in gene silencingResearchers in a University of Oregon lab have shed more light on the mechanism that regulates DNA methylation, a fundamental biological process in which a methyl group is attached to DNA, the genetic material in cells of living organisms.DNA methylation is essential for normal growth and development in plants and animals. It has been implicated in long-term memory, and irregularities in...

2008-12-05 09:34:57

The Stowers Institute's Workman Lab has discovered a novel histone demethylase protein complex characterized in work published today in Molecular Cell.The Histone H3 protein is an important component of chromatin, the packing material wrapping up chromosomal DNA and preventing unwanted transcription of the message encoded in the DNA. Histone H3 can be altered by adding (methylating) or removing (demethylating) methyl groups from the histone protein. When genes are transcribed, parts of...

0a867b0f6b1d4749b5d203b59eb7628a1
2008-11-25 12:20:00

Researchers at The Scripps Research Institute have figured out how a macromolecular machine is able to unwind the long and twisted tangles of DNA within a cell's nucleus so that genetic information can be "read" and used to direct the synthesis of proteins, which have many specific functions in the body.The scientists say that their findings, published in the November 23, 2008 online issue of Nature Structural & Molecular Biology, provide important new insights into this critical DNA...

64d23fb715067f93af7e52eb1ac051441
2008-05-19 09:45:00

An herb used in traditional medicine by many Middle Eastern countries may help in the fight against pancreatic cancer, one of the most difficult cancers to treat. Researchers at the Kimmel Cancer at Jefferson in Philadelphia have found that thymoquinone, an extract of nigella sativa seed oil, blocked pancreatic cancer cell growth and killed the cells by enhancing the process of programmed cell death.While the studies are in the early stages, the findings suggest that thymoquinone could...

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2008-05-08 14:15:00

MU scientist found mechanism that "Ëœsilences' unmatched genes during cellular reproduction When most people discover mold on their bread, they immediately throw it out. Others see a world of possibilities in the tiny fungus. A University of Missouri scientist, along with a collaborative research team, has examined a new mechanism in the reproductive cycle of a certain species of mold. This mechanism protects the organism from genetic abnormalities by "silencing" unmatched genes...

1f9157b8f0aa2e49aa1e2d543d5a447e
2008-04-02 11:38:25

Reshaping of the DNA scaffolding that supports and controls the expression of genes in the brain may play a major role in the alcohol withdrawal symptoms, particularly anxiety, that make it so difficult for alcoholics to stop using alcohol.The finding is reported by researchers at the University of Illinois at Chicago and the Jesse Brown VA Medical Center in the April 2 issue of the Journal of Neuroscience.DNA can undergo changes in function without any changes in inheritance or coded...


Word of the Day
siliqua
  • A Roman unit of weight, 1⁄1728 of a pound.
  • A weight of four grains used in weighing gold and precious stones; a carat.
  • In anatomy, a formation suggesting a husk or pod.
  • The lowest unit in the Roman coinage, the twenty-fourth part of a solidus.
  • A coin of base silver of the Gothic and Lombard kings of Italy.
'Siliqua' comes from a Latin word meaning 'a pod.'
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