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Latest Histone Stories

2012-04-12 11:21:29

The study has been published in the prestigious journal Molecular Cell Researchers at the Hospital de Mar Research Institute (IMIM) have discovered that the protein LOXL2 has a function within the cell nucleus thus far unknown. They have also described a new chemical reaction of this protein on histone H3 that would be involved in gene silencing, one of which would be involved in the progression of breast, larynx, lung and skin tumours. Led by Dr Sandra Peiró and published...

2012-04-10 09:15:14

The missing link that spans the gap between the genes and environment could be a sugar — in this case, a special one that regulates histone 3, part of the DNA backbone, said researchers from Baylor College of Medicine and the University of Georgia in a report that appears online in the Journal of Biological Chemistry. The sugar in question is called beta-N-acetylglucosamine or O-GlcNAc, said Dr. Richard Sifers, professor of pathology & immunology at BCM, and corresponding author...

2012-03-27 14:21:04

LONDON, March 27, 2012 /PRNewswire/ -- The ability to diagnose disease early has long been a goal in the medical arena. VolitionRX (VNRX.OB), a life sciences company, is pioneering scientific research into simple, cost-effective tools capable of diagnosing the early presence of disease via a blood test. (Photo: http://photos.prnewswire.com/prnh/20120327/NY77344 ) VolitionRX is developing its Nucleosomics(TM) technology to measure and identify the signatures of nucleosomes (a...

2012-03-14 13:56:38

A team of researchers led by scientists at The Rockefeller University has identified a novel mechanism by which influenza interferes with antiviral host response. The finding, reported in this week's issue of the journal Nature, shows that the immunosuppressive NS1 protein of the influenza A virus hijacks key regulators of antiviral gene function by mimicking a core component of gene regulating machinery. The results they describe have major implications for our understanding of the biology...

2012-03-12 11:33:30

Within all our cells lies two meters of DNA, highly ordered in a structure of less than 10 micro meters in diameter. Special proteins called histones act as small building bricks, organising our DNA in this structure. Preservation of the structure is necessary to maintain correct function of our genes, making histones detrimental for maintaining a healthy and functional body. The research group of Associate Professor Anja Groth from BRIC, University of Copenhagen, has just elucidated a...

2012-03-07 16:00:36

In the cell nucleus, DNA wraps around what are called histone proteins, forming regularly spaced spherical bodies called nucleosomes. Thus, large portions of the genetic material are inaccessible to the gene reading machinery. Scientists at the German Cancer Research Center have now simulated at high time resolution how short DNA segments repeatedly detach spontaneously from the nucleosome. The group has been the first to demonstrate that the spool-shaped histone proteins have an active role...

2012-03-07 15:43:18

Researchers at the RIKEN SPring-8 Center in Harima, Japan have clarified for the first time how chromatin in archaea, one of the three evolutionary branches of organisms in nature, binds to DNA. The results offer valuable clues into the evolution of chromatin structure in multi-cellular organisms and promise insights into how abnormalities in such structure can contribute to cancers and gene disorders. Three distinct evolutionary branches of organisms make up all natural forms of life on...

2012-03-02 01:17:19

Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, they have determined the 3-D structure and interactions of the histone chaperone Rtt106 down to the atomic details. "The interactions we described are important for gene silencing and the DNA damage response," says senior author Georges Mer, Ph.D., a Mayo Clinic structural...

2012-01-30 11:50:06

Glioblastomas grow extremely aggressively into healthy brain tissue and, moreover, are highly resistant to radiation therapy and chemotherapy. Therefore, they are regarded as the most malignant type of brain tumor. Currently available treatment methods are frequently not very effective against this type of cancer. Glioblastoma can affect people of all ages, but is less common in children than in adults. In order to gain a better understanding of the molecular processes involved in the...

2012-01-30 08:24:04

Washington University Pediatric Cancer Genome Project provides first evidence linking cancer to mutations in genes involved in DNA organization Researchers studying a rare, lethal childhood tumor of the brainstem discovered that nearly 80 percent of the tumors have mutations in genes not previously tied to cancer. Early evidence suggests the alterations play a unique role in other aggressive pediatric brain tumors as well. The findings from the St. Jude Children's Research Hospital...