Latest Histone Stories
At the same time that a cell's DNA gets duplicated, a third of it gets super-compacted into repetitive clumps called heterochromatin.
In order for cells of different types to maintain their identities even after repeated rounds of cell division, each cell must "remember" which genes were active before division and pass along that memory to its daughter cells.
While efforts to unlock the subtleties of DNA have produced remarkable insights into the code of life, researchers still grapple with fundamental questions.
Chromatin - the intertwined histone proteins and DNA that make up chromosomes – constantly receives messages that pour in from a cell’s intricate signaling networks: Turn that gene on. Stifle that one.
Researchers funded by the Biotechnology and Biological Sciences Research Council (BBSRC) at the John Innes Centre have made a discovery, reported this evening (24 July) in Nature, that explains how an organism can create a biological memory of some variable condition, such as quality of nutrition or temperature.
Scientists at Penn State University have achieved a major milestone in the attempt to assemble, in a test tube, entire chromosomes from their component parts.
DNA is under constant attack, from internal factors like free radicals and external ones like ionizing radiation.
Tumor suppressor genes normally control the growth of cells, but cancer can spring up when these genes are silenced by certain chemical reactions that modify chromosomes.
To understand the emerging science of epigeneticsâ€”a field that describes how genes may be regulated without altering the underlying DNA itselfâ€”scientists are deciphering the many ways in which enzymes act on the proteins surrounding DNA within cells.
In the case of DNA, the package can be as important as its contents, new work with fruit flies reveals.
- A woman chauffeur.
- A woman who operates an automobile.