Latest Histone Stories
While efforts to unlock the subtleties of DNA have produced remarkable insights into the code of life, researchers still grapple with fundamental questions.
Chromatin - the intertwined histone proteins and DNA that make up chromosomes – constantly receives messages that pour in from a cell’s intricate signaling networks: Turn that gene on. Stifle that one.
Researchers funded by the Biotechnology and Biological Sciences Research Council (BBSRC) at the John Innes Centre have made a discovery, reported this evening (24 July) in Nature, that explains how an organism can create a biological memory of some variable condition, such as quality of nutrition or temperature.
Scientists at Penn State University have achieved a major milestone in the attempt to assemble, in a test tube, entire chromosomes from their component parts.
DNA is under constant attack, from internal factors like free radicals and external ones like ionizing radiation.
Tumor suppressor genes normally control the growth of cells, but cancer can spring up when these genes are silenced by certain chemical reactions that modify chromosomes.
To understand the emerging science of epigeneticsâ€”a field that describes how genes may be regulated without altering the underlying DNA itselfâ€”scientists are deciphering the many ways in which enzymes act on the proteins surrounding DNA within cells.
In the case of DNA, the package can be as important as its contents, new work with fruit flies reveals.
The function of histones -- the proteins that enable yards of DNA to be crammed into a single cell -- depends on a number of chemical tags adorning their exterior.
In a study published in the journal Developmental Cell, Sarah Millar PhD, professor of Dermatology and Cell & Developmental Biology at the University of Pennsylvania School of Medicine, and colleagues demonstrate that a pair of enzymes called HDACs are critical to the proper formation of mammalian skin.