Latest Histone Stories
The function of histones -- the proteins that enable yards of DNA to be crammed into a single cell -- depends on a number of chemical tags adorning their exterior.
In a study published in the journal Developmental Cell, Sarah Millar PhD, professor of Dermatology and Cell & Developmental Biology at the University of Pennsylvania School of Medicine, and colleagues demonstrate that a pair of enzymes called HDACs are critical to the proper formation of mammalian skin.
A new study reveals that two enzymes help immune cells deploy pathogen-killing traps by unraveling and using the chromatin (DNA and its associated proteins) contained in the cells' nuclei to form defensive webs.
The genetic inherited material DNA was long viewed as the sole bearer of hereditary information.
Post-translational modifications of histones play an important role in regulating chromatin dynamics and function.
Like cats, human cells have a finite number of lives-once they divide a certain number of times (thankfully, more than nine) they change shape, slow their pace, and eventually stop dividing, a phenomenon called "cellular senescence".
By creating a "map" of histone modifications in fat cells, investigators have discovered two new factors that regulate fat formation, a key step on the road to better understanding obesity, diabetes and other metabolic disorders.
Stress has become one of the major disease states in the developed world.
On average, one hundred billion cells in the human body divide over the course of a day.
The DNA genomes of organisms whose cells possess nuclei are packaged in a highly characteristic fashion.
- The analysis of literature, focusing on the words and grammar to the exclusion of context or literary merit.