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Latest History and naming of human leukocyte antigens Stories

2014-06-04 23:07:57

Omixon and CHOP have used next-generation sequencing tools to significantly advance HLA typing, characterizing whole genes with variations fully phased. Cambridge, MA (PRWEB) June 04, 2014 Global bioinformatics software company Omixon, headquartered in Budapest with US offices in Cambridge, MA, announces an exclusive licensing agreement with The Children’s Hospital of Philadelphia (CHOP) to commercialize a new Next Generation Sequencing (NGS) HLA genotyping assay, for use on the...

2012-04-10 13:53:32

New method for direct identification of antigens The immune system is a vital part of our defenses against pathogens, but it can also attack host tissues, resulting in autoimmune disease. The antigens that induce destructive immune reactions can now be identified directly — without any prior knowledge of their possible structure. Molecules that activate immune responses, generically termed antigens, are recognized by circulating immune cells. In the case of autoimmune reactions,...

2012-01-10 23:20:43

The cocktail maintaining immune gene variation The great variation of a specific form of immune genes makes organ transplants so complicated. On the other hand, we need such a great variability in order to resist infectious diseases. This is why it also plays a major role in the selection of sexual partners. Up until now, the mechanisms for maintaining this standing genetic variation have remained an evolutionary puzzle. In a study of sticklebacks, researchers from the Max Planck Institute...

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2011-08-26 05:05:08

  Sexual encounters with Neanderthals produced offspring who inherited vital genes that have helped modern humans combat illness and disease, according to a study published Thursday in the journal Science. The scientists extracted material from the leg of a Neanderthal and the fingerbone of a Denisovan, an apparent sister species, which yielded readable DNA.  An analysis of the DNA revealed that most of us have some of the genes of these ancient humans. Indeed, the...

2011-07-20 07:03:35

(Ivanhoe Newswire) "“ Avoiding kidney mismatching is beneficial in pediatric kidney transplant patients, however, the likelihood of finding a matching donor must be considered against the wait time for a possible donation, according to this study. "Although avoiding HLA [human leukocyte antigen; cell surface antigens that regulate host cell responses to transplanted cells] antigen mismatching has been shown to benefit long-term graft survival, it has raised concerns about disadvantaging...

2011-07-18 16:24:01

Avoiding HLA-DR mismatching appears to be beneficial in pediatric kidney transplant patients, however the likelihood of finding a matching donor must be considered against the wait time for a possible donation, according to a report in the July issue of Archives of Surgery, one of the JAMA/Archives journals. "Although avoiding HLA [human leukocyte antigen; cell surface antigens that regulate host cell responses to transplanted cells] antigen mismatching has been shown to benefit long-term...

2010-09-25 00:45:26

A simple, inexpensive blood test could soon help doctors halt organ rejection before it impairs transplanted hearts and kidneys. "In the past, we couldn't spot rejection episodes until they harmed the organ," said Atul Butte, MD, PhD, who is co-senior author of the new research and an associate professor of medical informatics and of pediatrics at the Stanford University School of Medicine, in addition to director of the Center for Pediatric Bioinformatics at Lucile Packard Children's...

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2009-07-06 12:40:00

 The future of organ transplantation could include microscopic beads that create "designer" immune cells to help patients tolerate their new organ, Medical College of Georgia researchers say."It's absolutely natural," says Dr. Anatolij Horuzsko, reproductive immunologist at the MCG Center for Molecular Chaperone/Radiobiology and Cancer Virology, who has used the approach successfully in mice with skin grafts.The degradable microparticles deliver the most powerful known form of HLA-G, a...

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2008-07-15 13:49:16

MU engineer is developing light-based technique sensitive enough to detect a single disease molecule If a doctor could identify a single molecule indicating the presence of a disease before the disease has a chance to harm the patient, the practice of medicine and the health of patients would be greatly improved. That's the potential of a new device being developed by a University of Missouri engineer that is designed to aid in the diagnosis of disease. This technique, which is based on light...


Word of the Day
holluschickie
  • A 'bachelor seal'; a young male seal which is prevented from mating by its herd's older males (mated bulls defending their territory).
This comes from the Russian word for 'bachelors.'
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