Latest HLA-B Stories

2009-04-15 14:14:50

People with the ability to stave off AIDS for years after initial infection by HIV have been called "long-term non-progressors" or "elite controllers." One component of this remarkable resistance comes from an individual's HLA genes. Long-term non-progressors tend to have HLA genes that help the immune system recognize and fight HIV more efficiently. A team of researchers from the Emory Vaccine Center studying HIV-infected people with particularly effective HLA genes has observed how the...

2009-04-13 07:58:15

Mutations that help HIV hide from the immune system undermine the virus's ability to replicate, show an international team of researchers in the April 13 issue of the Journal of Experimental Medicine. The study was published online on March 23. When HIV infects a cell, a complex of human immune proteins called HLA (short for human leukocyte antigen) alert killer T cells by displaying bits of the virus on the surface of the cell. The T cells recognize these HIV fragments and mobilize an...

2008-10-10 15:00:09

DEAR DR. DONOHUE: My brother was recently told he has ankylosing spondylitis. He's in his early 50s and has posture like Ed Sullivan, who had the same disease. He gives himself a shot of Humira. He has a lot of pain. Is ankylosing spondylitis inherited? How likely is it that some of the rest of us nine kids could inherit it? - K.H. ANSWER: Ankylosing (AN-kuh-LOW-sing) spondylitis (SPAWN-duh-LITE- is) is arthritis that affects primarily the backbones, the vertebrae. It often begins as a dull...

2008-08-25 12:01:20

LinkMeds wholly owned subsidiary Olerup SSP has developed a new test that detects genetic variations in the human leucocyte antigen system that indicates risk for severe adverse reactions to Abacavir in HIV patients. The test is marketed and sold by Qiagen. The new test is CE marked in Europe for in vitro diagnostic use and available for research use in other countries. According to the company, HIV patients carrying the HLA-B5701 marker have a 60% higher risk to develop hypersensitivity...

2008-08-19 03:00:13

HLA-B*5701 biomarker indicates risk for severe adverse reactions to Abacavir / Experts expect more tests for similar markers in the future Venlo, The Netherlands - August 19, 2008 - QIAGEN (Nasdaq: QGEN; Frankfurt Prime Standard: QIA) today announced that it has introduced a new molecular diagnostic test to type the HLA-B*5701 allele, a genetic variation in the Human Leucocyte Antigen (HLA) system. HIV patients carrying the HLA-B*5701 marker have a 60% higher risk to develop...

2008-03-21 00:05:00

Researchers at University of Cape Town in South Africa reported Friday the discovery of a variation of an immunity gene that weakens the human immunodeficiency virus (HIV), slowing down the progression of AIDS and making the virus less potent if transmitted to others. HIV is the virus that causes AIDS, and like all viruses it must invade and takeover cells in order to replicate itself. But in order for the virus to successfully hijack the cell, it must evade several genes, including an...

Word of the Day
  • A blustering, bullying fellow; a pot-valiant braggart; a bully.
This word is named for Draw-Can-Sir, a character in George Villiers' 17th century play The Rehearsal.