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Last updated on April 18, 2014 at 21:21 EDT

Latest HMG-CoA reductase Stories

2011-03-02 16:14:09

A promising new way to inhibit cholesterol production in the body has been discovered, one that may yield treatments as effective as existing medications but with fewer side-effects. In a new study published in the journal Cell Metabolism, a team of researchers from the UNSW School of Biotechnology and Biomolecular Sciences - led by Associate Professor Andrew Brown "“ report that an enzyme - squalene mono-oxygenase (SM) - plays a previously unrecognised role as a key checkpoint in...

2010-02-08 18:09:00

WILMINGTON, Del., Feb. 8 /PRNewswire-FirstCall/ -- AstraZeneca (NYSE: AZN) today announced that the US Food and Drug Administration (FDA) has approved CRESTOR® (rosuvastatin calcium) to reduce the risk of stroke, myocardial infarction (heart attack) and arterial revascularization procedures in individuals without clinically evident coronary heart disease but with an increased risk of cardiovascular disease (CVD) based on age (men greater than or equal to 50 and women...

2008-09-17 03:00:10

By Rea, Philip A The curiosity of biochemists, mixed with some obvious economic incentives, created a family of powerful cardiovascular drugs In 1966, Akira Endo, a young Japanese biochemist, started an adventure that would ultimately save thousands, if not millions, of lives. Only 33 years old at the time, Endo was a research scientist at Sankyo-a pharmaceutical company, later known as Daiichi Sankyo, in Tokyo-where he was looking for enzymes in fungal extracts for improving the quality of...

2008-08-12 03:00:05

WASHINGTON - Patients taking some common medications for high cholesterol and irregular heartbeats can suffer severe muscle damage because of a problem in the way the drugs interact, the government warned Friday. The Food and Drug Administration said doctors should use extra care when prescribing Zocor, generic Zocor or Vytorin to patients who are also taking amiodarone, a heart rhythm drug marketed as Cordarone or Pacerone. The danger is higher for patients taking more than 20...

2005-08-11 19:05:00

72 years ago, the first evidence for end-product feedback regulation of a biosynthetic pathway was demonstrated when Rudolph Shoenheimer observed that mice synthesized large amounts of cholesterol when fed a low-cholesterol diet, but this synthesis stopped when the mice were fed cholesterol. In later years, many details of this cholesterol feedback were worked out, but the main mechanism by which cells in the liver sense cholesterol and thus regulate cholesterol production remained unknown....