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Latest Homologous recombination Stories

2011-10-24 10:15:15

Findings suggest how cancer cells can become resistant to DNA damage-inducing treatments An international team of scientists led by UC Davis researchers has discovered that DNA repair in cancer cells is not a one-way street as previously believed. Their findings show instead that recombination, an important DNA repair process, has a self-correcting mechanism that allows DNA to make a virtual u-turn and start over. The study's findings, which appear in the Oct. 23 online issue of the...

2011-10-06 13:08:46

In children with genomic disorders, often a gamete — egg or sperm — has gone disastrously awry with either a duplication or deletion of genetic material that results in physical and neurological problems for the subsequent child. Previous studies have identified a procedure called nonallelic homologous recombination, which occurs during meiosis or sexual cell division, as the event that most commonly occurs and results in this mistake in DNA. Researchers from Baylor College...

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2011-04-24 16:07:21

In stark contrast to normal cells, which only divide a finite number of times before they enter into a permanent state of growth arrest or simply die, cancer cells never cease to proliferate. Now, scientists at the Salk Institute for Biological Studies have uncovered an important clue to one of the mechanisms underlying cancer cell immortality.Their findings, published in the April 22, 2011 issue of Molecular Cell, reveal an unanticipated structure at chromosome ends, which could be a key...

2011-04-19 13:07:14

Berkeley Lab Scientists Discover Dynamic Double-Strand Break Repair in Heterochromatin DNA is under constant attack, from internal factors like free radicals and external ones like ionizing radiation. About 10 double-strand breaks "“ the kind that snap both backbones of the double helix "“ occur every time a human cell divides. To prevent not only gene mutations but broken chromosomes and chromosomal abnormalities known to cause cancer, infertility, and other diseases in humans,...

2011-04-07 16:50:16

Thematic program focuses on DNA replication, recombination and repair DNA's role as the master blueprint of the cell means that even small sequence changes can have catastrophic consequences. For this reason, much of our understanding of cancer development comes from studying how cells copy DNA and repair sequence errors -- and how these processes can go wrong. Next week, a thematic program at the American Society for Biochemistry and Molecular Biology's annual meeting at the Experimental...

2011-04-04 11:00:00

PARIS, April 4, 2011 /PRNewswire/ -- Cellectis (Alternext: ALCLS), the genome engineering specialist, has announced today that it has signed a license agreement with a pharmaceutical company covering certain uses of its homologous recombination technology patents and patent applications, in the oncology therapeutic field. This agreement has triggered an immediate payment of euro 3M ($4.2M) to Cellectis. Further details of the arrangement have not been disclosed. About Cellectis...

2011-01-31 13:37:28

DNA was originally thought to have a single function:  to help cells make the proteins they need.  Any DNA that is not immediately required to produce proteins was written off as "junk" and deemed unworthy of study.  Recently, however, it has become clear that junk DNA performs a wide range of important tasks.  As a result, attention is shifting to asking why some organisms have so much of it and other organisms so little.  A particular puzzle is posed by so-called...

2010-12-11 00:32:30

Scientists have discovered how a network of repair proteins enables bacteria to prioritise the repair of the most heavily used regions of the DNA molecules that carry the instructions necessary for living cells to function. The research, carried out by academics at the University of Bristol and published in Molecular Cell (Dec. 2010), reveals that there are greater similarities between the DNA repair systems of bacteria and humans than had been suspected. When the chemical "letters" in a...

2010-08-31 13:33:04

An Iowa State University team of researchers has developed a type of hybrid proteins that can make double-strand DNA breaks at specific sites in living cells, possibly leading to better gene replacement and gene editing therapies. Bing Yang, assistant professor of genetics, development and cell biology, and his colleagues developed the hybrid protein by joining parts of two different bacterial proteins. One is called a TAL effector, which functions to find the specific site on the gene that...

2010-08-12 15:05:00

Molecular connection is crucial to fix DNA double-strand breaks A team of investigators led by a physician-scientist at The University of Texas MD Anderson Cancer Center has shown for the first time that the small protein SUMO can team up with the replication protein A (RPA) complex to facilitate DNA repair. The study is published in the Aug. 13 edition of the journal Molecular Cell. RPA 70 is a component of multiprotein machinery called the RPA complex, which plays a crucial role in DNA...


Word of the Day
call-note
  • The call or cry of a bird or other animal to its mate or its young.
'Call-note' is newer than 'bird-call,' which originally referred to 'an instrument for imitating the note of birds' but now also refers to 'the song or cry of a bird.'
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