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Latest Homology directed repair Stories

2010-07-02 20:12:59

Tufts biologists' findings have potential to advance development of new cancer drugs Tufts University researchers in the School of Arts and Sciences have pinpointed a key cellular protein that repairs damaged DNA molecules but may also promote the development of cancer. Assistant Professor of Biology Mitch McVey and his research team report that DNA polymerase theta, or PolQ, promotes an inaccurate repair process, which can ultimately cause mutations, cell death or cancer. The research is...

2009-10-02 09:14:48

Understanding how serious breaks in DNA are repaired may help researchers to make cancer therapy more effective Researchers at The Scripps Research Institute have found, crystallized, and biologically characterized a poorly defined component of a key molecular complex that helps people to avoid cancer, but that also helps cancer cells resist chemotherapy. The research was published in the October 2, 2009 issue of the journal Cell. This biological machine"”the Mre11-Rad50-Nbs1 (MRN)...

2009-07-17 09:08:00

Researchers at Washington University School of Medicine in St. Louis have shed new light on a process that fixes breaks in the genetic material of the body's cells. Their findings could lead to ways of enhancing chemotherapy drugs that destroy cancer cells by damaging their DNA. Using yeast cells, the scientists studied protein molecules that have an important role in homologous recombination, which is one way that cells repair breaks in the DNA double helix. The process in yeast is similar...

2009-06-15 16:36:00

A person's DNA is often damaged by a number of different chemical contaminants, and if not repaired properly, it can lead to the development of cancer and other diseases. Through an international collaboration, University of Alberta researchers Chris Le and Michael Weinfeld have discovered how damaged DNA is recognized and repaired. This could lead to improved treatment of cancer and other diseases.The team, from the Faculty of Medicine & Dentistry, used a new technology to monitor the...

2009-01-07 13:51:36

A protein known for signaling cell injuries and preventing damaged cells from proliferating also repairs DNA, a published U.S. university study found. Mre11 -- part of a complex of proteins involved in DNA damage repair in mammals -- recognizes the damage and rapidly relocates to where a strand of genetic material is broken and could possibly join to a different DNA molecule, the University of Michigan researchers said in the journal Cell. Earlier research suggested Mre11 functioned only as a...


Word of the Day
drawcansir
  • A blustering, bullying fellow; a pot-valiant braggart; a bully.
This word is named for Draw-Can-Sir, a character in George Villiers' 17th century play The Rehearsal.
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