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Latest Hsp27 Stories

2011-09-28 11:37:39

Breast cancer cells that mutate to resist drug treatment survive by establishing tiny pumps on their surface that reject the drugs as they penetrate the cell membrane — making the cancer insensitive to chemotherapy drugs even after repeated use. Researchers have found a new way to break that resistance and shut off the pumps by genetically altering those breast cancer cells to forcibly activate a heat-shock protein called Hsp27. This protein regulates several others, including the...

2011-04-14 07:00:00

BOTHELL, Wash. and VANCOUVER, British Columbia, April 14, 2011 /PRNewswire/ -- OncoGenex Pharmaceuticals, Inc. (NASDAQ: OGXI), today announced that the European Patent Office (EPO) has granted European Patent Number EP1545561 entitled "Oligonucleotides for Treatment of Prostate and other Cancers." The patent, licensed from The University of British Columbia, includes coverage for antisense and siRNA compositions that reduce the amount of active Heat Shock Protein 27 (Hsp27) in Hsp27...

2011-04-04 12:00:00

BOTHELL, Wash. and VANCOUVER, British Columbia, April 4, 2011 /PRNewswire/ -- OncoGenex Pharmaceuticals, Inc. (NASDAQ: OGXI) announced today that preclinical data utilizing their pipeline compound OGX-427 was presented at the AACR 102nd Annual Meeting 2011. The study demonstrated the ability of OGX-427 to inhibit Heat Shock Protein 27 (Hsp27), a cell-survival protein believed to play an important role in the proliferation of castrate resistant prostate cancer (CRPC) and resistance to...

2010-12-03 15:42:52

Study suggests memory-destroying tau tangles proliferate when Hsp27 regulation is compromised Dynamic regulation of the chaperone protein Hsp27 was required to get rid of abnormally accumulating tau in the brains of mice genetically modified to develop the memory-choking tau tangles associated with Alzheimer's disease, a University of South Florida-led study found. Researchers at the USF Health Byrd Alzheimer's Institute demonstrated that the effective switching of Hsp27 between its active...

2010-09-21 21:51:44

Patients who experience physical or psychological stress "“ including rigorous exercise "“ one or two days before a cancer treatment might be unknowingly sabotaging their therapy, new research suggests. Stress in the body "“ even physical stress caused by intense exercise "“ activates a stress-sensitive protein that can spark a series of events that allow cancer cells to survive such treatments as chemotherapy and radiation, according to the research. Though the study...


Word of the Day
bellycheer
  • Good cheer; viands.
  • To revel; to feast.
The word 'bellycheer' may come from 'belle cheer', "good cheer".
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