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Latest Hsp70 Stories

CHEM-Grimes-Mohanan-NOD2_Research
2014-07-20 10:59:47

Tracey Bryant, University of Delaware University of Delaware researchers have identified a protein, hiding in plain sight, that acts like a bodyguard to help protect and stabilize another key protein, that when unstable, is involved in Crohn’s disease. The fundamental research points to a possible pathway for developing an effective therapy for the inflammatory bowel disease. The research, by Catherine Leimkuhler Grimes, assistant professor of chemistry and biochemistry at UD, and...

2012-03-09 01:43:43

Max Planck scientists identify key player of protein folding Proteins are the molecular building blocks and machinery of cells and involved in practically all biological processes. To fulfil their tasks, they need to be folded into a complicated three-dimensional structure. Scientists from the Max Planck Institute of Biochemistry (MPIB) in Martinsried near Munich, Germany, have now analysed one of the key players of this folding process: the molecular chaperone DnaK. “The...

2012-01-31 09:49:38

Researchers from UCLA's Jonsson Comprehensive Cancer Center have identified a cell-permeable peptide that inhibits a hepatitis C virus protein and blocks viral replication, which can lead to liver cancer and cirrhosis. This finding by Dr. Samuel French, an assistant professor of pathology and senior author of the study, builds on previous work by the French laboratory that identified two cellular proteins that are important factors in hepatitis C virus infection. French and his team...

2012-01-14 01:38:57

Large conformational changes without ATP consummation A special group of proteins, the so-called chaperons, helps other proteins to obtain their correct conformation. Until now scientists supposed that hydrolyzing ATP provides the energy for the large conformational changes of chaperon Hsp90. Now a research team from the Nanosystems Initiative Munich could prove that Hsp90 utilizes thermal fluctuations as the driving force for its conformational changes. The renowned journal PNAS reports...

2011-01-27 09:00:00

NEW YORK, Jan. 27, 2011 /PRNewswire-USNewswire/ -- The Alzheimer's Drug Discovery Foundation (ADDF) announced today that it has awarded a grant of $195,000 to ALS Biopharma, LLC to develop therapeutics targeted at clearing toxic proteins implicated in Alzheimer's disease. (Logo: http://photos.prnewswire.com/prnh/20090805/DC57332LOGO) The program will identify and develop small-molecule brain-penetrant inducers of heat shock protein 70 (Hsp70). Hsp70 clears two proteins believed to be...

2010-07-07 12:44:22

Researchers at NUI Galway have made a discovery that could lead to the development of more effective treatments for a number of diseases. They have shown that a protein produced when cells are stressed interacts with a stress sensor allowing cells to survive conditions of intense stress. Understanding this interaction may help scientists interfere with cancer cells so the cells can no longer survive exposure to stressful conditions. These findings are published next week in the online, open...

2010-01-26 15:18:12

Contrary to prevailing wisdom, a new study from plant biologists at UC Davis shows that proteins of the Hsp70 family do indeed chaperone proteins across the membranes of chloroplasts, just as they do for other cellular structures. The findings are published online in the January issue of the journal The Plant Cell. One of the most crucial tasks in a living cell is to move things across membranes, both in and out of the cell and between different compartments inside. Chloroplasts are...

2010-01-15 17:35:50

Proteosome inhibitors can rescue mutant proteins without altering the DNA of mutant genes Researchers at Fox Chase Cancer Center have demonstrated how it could be possible to treat genetic diseases by enhancing the natural ability of cells to restore their own mutant proteins. In particular, they found that drugs called proteosome inhibitors could provide one way of manipulating cells into producing more of a so-called chaperone protein, named Hsp70, which helps amino acid chains fold into...

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2009-11-17 07:55:00

A powerful new breast cancer treatment could result from packaging one of the newer drugs that inhibits cancer's hallmark wild growth with another that blocks a primordial survival technique in which the cancer cell eats part of itself, researchers say. While they are powerful killers of some breast cancer cells, new drugs called histone deacetylase inhibitors, or HDAC inhibitors, also increase self-digestion, or autophagy, in surviving, mega-stressed cells, Medical College of Georgia Cancer...

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2009-10-30 10:00:29

Like yoga for office drones, cells do have coping strategies for stress. Heat, lack of nutrients, oxygen radicals "“ all can wreak havoc on the delicate internal components of a cell, potentially damaging it beyond repair. Proteins called HSPs (heat shock proteins) allow cells to survive stress-induced damage. Scientists have long studied how HSPs work in order to harness their therapeutic potential. Donna George, PhD, Associate Professor of Genetics, and Julie Leu, PhD, Assistant...


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.