Quantcast

Latest Hsp90 Stories

2014-05-28 08:31:42

LAUSANNE, Switzerland, May 28, 2014 /PRNewswire/ -- Debiopharm Group(TM) (Debiopharm), a Swiss-based global biopharmaceutical company developing prescription drugs that target unmet medical needs as well as companion diagnostics, today announced that new data on the investigational compounds Debio 1143 (SMAC mimetic), Debio 1347/CH5183284 (FGFR 1,2,3 inhibitor), and Debio 0932 (Hsp90 inhibitor) will be presented at the 50th American Society of Clinical Oncology (ASCO) Annual...

2014-04-09 10:50:26

By incapacitating the activities of a protein that guides other proteins to fold into a stable shapes, Fox Chase Cancer Center researchers shut off the spigot for two proteases that help ovarian cancer cells chew their way out of the tissue they grow in and dig in at new locations. Building on earlier work that showed that inhibition of heat shock proteins—the protein origami helpers—limited metastases in ovarian cancer in mice, Shane W. O'Brien, MS, Scientific Assistant at Fox Chase...

Researchers Discover Achilles Heel Of The Plasmodium And Aim A Molecular Arrow To Destroy It
2014-03-12 15:01:18

Université de Genève The malaria parasite is particularly pernicious since it is built to develop resistance to treatments. The lack of new therapeutic approaches also contributes to the persistence of this global scourge. A study led by Didier Picard, professor at the Faculty of Sciences of the University of Geneva (UNIGE), Switzerland, describes a new class of molecules targeting the two problems at the same time. Using ultra sophisticated computerised modelling tools, the researchers...

Blind Cavefish Offer Evidence For Long-debated Mechanism Of Evolutionary Change
2013-12-13 11:16:07

Marine Biological Laboratory In a blind fish that dwells in deep, dark Mexican caves, scientists have found evidence for a long-debated mechanism of evolutionary change that is distinct from natural selection of spontaneously arising mutations, as reported this week in the journal Science. The eyeless cavefish Astyanas mexicanus is "a special system in which we can look at evolution in action," says article co-author William Jeffery, a senior adjunct scientist at the Marine Biological...

Additive Found In Dog Food May Prevent A Disabling Chemotherapy Side Effect
2013-09-20 08:47:59

April Flowers for redOrbit.com - Your Universe Online A chemical commonly used as a dog food preservative might prevent the kind of painful nerve damage found in the hands and feet of four out of five cancer patients taking the chemotherapy drug Taxol. A team of Johns Hopkins researchers have been working with cells in test tubes and mice to investigate the Food and Drug Administration (FDA)-approved dog food preservative. The preservative, an antioxidant called ethoxyquin, has been...

Stress-related Protein Increases Progression Of Alzheimer’s Disease
2013-09-04 10:59:51

[ Watch The Video - Untangling the Brain ] University of South Florida USF-led study suggests FKBP51 is a new treatment target for diseases with tau pathology A stress-related protein genetically linked to depression, anxiety and other psychiatric disorders contributes to the acceleration of Alzheimer’s disease, a new study led by researchers at the University of South Florida has found. The study is published online today in the Journal of Clinical Investigation. When...

2013-04-12 16:04:34

A major factor in the advance of heart disease is the death of heart tissue, a process that a team of scientists at Temple University School of Medicine's (TUSM) Center for Translational Medicine think could be prevented with new medicines. Now, the researchers are one step closer to achieving that goal, thanks to their discovery of a key molecule in an unexpected place in heart cells — mitochondria, tiny energy factories that house the controls capable of setting off cells'...

2012-04-24 12:37:03

A cellular protein called HDAC6, newly characterized as a gatekeeper of steroid biology in the brain, may provide a novel target for treating and preventing stress-linked disorders, such as depression and post-traumatic stress disorder (PTSD), according to research from the Perelman School of Medicine at the University of Pennsylvania. Glucocorticoids are natural steroids secreted by the body during stress. A small amount of these hormones helps with normal brain function, but their excess...


Word of the Day
bellycheer
  • Good cheer; viands.
  • To revel; to feast.
The word 'bellycheer' may come from 'belle cheer', "good cheer".
Related