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Latest Human leukocyte antigen Stories

Modern Spy-Like Immune Gene May Have Come From Neanderthals
2013-11-24 06:03:36

Ranjini Raghunath for redOrbit.com - Your Universe Online A team of European researchers has recently discovered a protein molecule that helps the immune system identify threats and invaders. The molecule, a receptor belonging to the human leukocyte antigen (HLA) system, may have been inherited from Neanderthals, they report. HLA receptors help the immune system identify threats by tagging cells as either friendly or foreign. When a protein looks suspicious, immune cells called...

Behcet’s Disease Has Genetic Link To Ancient Silk Road Trade Route
2013-01-07 10:42:03

Lawrence LeBlond for redOrbit.com - Your Universe Online Researchers continuing the study of the human genome have mapped out four new regions that are associated with a painful and often dangerous condition–Behcet´s disease–found in people with a lineage to ancestors along the Silk Road. The Silk Road was used as an important trade route for nearly 2,000 years, linking the Far East and Europe. But along with the trade of goods and cultures, also came the exchange of...

2012-09-04 23:22:57

Discovery will lead to new screening protocol to better match patients and donors A team of scientists led by a bone marrow transplant researcher at Fred Hutchinson Cancer Research Center has shed new light on why most bone marrow transplant patients who receive tissue-matched cells from unrelated donors still suffer acute graft-versus-host disease (GVHD). The answer appears to lie in the discovery of previously undetected genetic differences in the DNA of patients and unrelated marrow...

2012-08-04 02:33:57

Human HLA genes — the genes that allow our immune system to tell the difference between our own cells and foreign invaders — are evolving much more rapidly than previously thought, according to an article online on August 3rd in Trends in Genetics. The resulting degree of variation improves our ability to fight off disease, but could also present challenges to current worldwide efforts aimed at identifying potential donors for patients undergoing stem cell transplantation....

2012-07-24 02:28:14

SAN DIEGO and CARLSBAD, Calif., July 24, 2012 /PRNewswire/ -- Gen-Probe Incorporated (NASDAQ: GPRO) and Life Technologies Corporation (NASDAQ: LIFE) today announced they have signed a distribution agreement for SeCore(®) HLA Sequence-Based Typing (SBT) kits for use with Life Technologies' 3500 Dx Genetic Analyzer. (Logo: http://photos.prnewswire.com/prnh/20120312/LA68580LOGO) Under the terms of the agreement, Gen-Probe's LIFECODES unit will have co-exclusive rights to sell SeCore SBT...

2012-05-29 14:21:11

ST. PAUL, Minn., May 29, 2012 /PRNewswire-iReach/ -- MD Bioproducts launches a new subtype specific antibody as a marker for ankylosing spondylitis (AS): HLA-B*2705. The anti-HLA-B*2705 antibody, clone MARB4, has been validated for use in flow cytometry, tissue staining and immunoprecipitation. (Photo: http://photos.prnewswire.com/prnh/20120529/CG15198) Ankylosing spondylitis (AS) is a chronc inflammatory arthritis. It is characterized by inflammation of the joints between the spinal...

2012-05-29 08:12:26

Researchers identify mechanism key in drug allergy Adverse drug reactions are a major issue that cause harm, are costly and restrict treatment options for patients and the development of new drugs. A groundbreaking finding by researchers from the La Jolla Institute for Allergy & Immunology could lead to a new way to dramatically improve drug safety by identifying drugs at risk to cause potentially fatal genetic-linked hypersensitivity reactions before their use in man....

2012-05-22 23:00:55

Research links abacavir hypersensitivity reactions to attacks by body's own immune system Potentially severe hypersensitivity reactions to the anti-HIV drug abacavir occur through an autoimmune mechanism, resulting from the creation of drug-induced immunogens that are attacked by the body's immune system, according to a study published online by the journal AIDS, official journal of the International AIDS Society. AIDS is published by Lippincott Williams & Wilkins, a part of Wolters...

2012-04-04 10:28:04

CARLSBAD, Calif., April 4, 2012 /PRNewswire/ -- Life Technologies Corporation (NASDAQ: LIFE) today announced that it is working with several partners to develop applications for its Ion Personal Genome Machine (PGM(TM)) system in HLA (human leukocyte antigen) analysis. HLAs are found on the surfaces of all cells in the body, and individuals vary widely in the combination of HLA sub-types found in their tissues. Tissue typing by HLA analysis is an essential component of determining organ...

2012-03-14 13:52:39

Model may allow development of individualized immunotherapies against cancer and infection Columbia University Medical Center (CUMC) scientists have developed a way to recreate an individual's immune system in a mouse. The "personalized immune mouse" offers researchers an unprecedented tool for individualized analysis of abnormalities that contribute to type 1 diabetes and other autoimmune diseases, starting at the onset of disease. The findings were published today in the online edition...