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Latest Human leukocyte antigen Stories

2010-04-20 07:45:24

The findings point to a new drug target for type 1 diabetes and other autoimmune diseases Scientists from The Scripps Research Institute have provided an answer to the 40-year-old mystery of how certain genetic mutations lead to Type 1 diabetes. This new molecular understanding could lead to novel therapies for Type 1 diabetes and other autoimmune diseases. The study was published in an advanced, online issue of the Journal of Clinical Investigation on April 19, 2010, and will appear in the...

2010-04-08 08:57:12

A new study shows that smoking may increase the risk of multiple sclerosis (MS) in people who also have specific established risk factors for MS. The research is found in the April 7, 2010, online issue of Neurology®, the medical journal of the American Academy of Neurology. The research involved 442 people with MS and 865 people without the disease from three studies: the Nurses' Health Study I/Nurses' Health Study II, the Tasmanian MS Study and the Swedish MS Study....

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2009-07-06 12:40:00

 The future of organ transplantation could include microscopic beads that create "designer" immune cells to help patients tolerate their new organ, Medical College of Georgia researchers say."It's absolutely natural," says Dr. Anatolij Horuzsko, reproductive immunologist at the MCG Center for Molecular Chaperone/Radiobiology and Cancer Virology, who has used the approach successfully in mice with skin grafts.The degradable microparticles deliver the most powerful known form of HLA-G, a...

2009-06-02 08:09:04

Recent genetic studies have revealed several new sites of genes that are risk factors for developing rheumatoid arthritis (RA). The strongest association with anti-citrullinated protein antibody (ACPA)-positive RA (ACPAs are autoantibodies detected in RA that are used as a major diagnostic tool) has been found for the HLA-DRB1 gene, and this site seems to play a central role in susceptibility to the disease in Caucasian populations. Previous studies have shown a high increase in the risk of...

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2009-05-04 07:12:14

Ten years ago, Stanford University School of Medicine scientist Emmanuel Mignot, MD, PhD, and his colleagues made headlines when they identified the culprit behind the sleep disorder narcolepsy. Now Mignot and his collaborators have shown for the first time that a specific immune cell is involved in the disorder "” confirming experts' long-held suspicion that narcolepsy is an autoimmune disease. The work, which will be published online May 3 in Nature Genetics, could lead to better...

2009-04-13 07:58:15

Mutations that help HIV hide from the immune system undermine the virus's ability to replicate, show an international team of researchers in the April 13 issue of the Journal of Experimental Medicine. The study was published online on March 23. When HIV infects a cell, a complex of human immune proteins called HLA (short for human leukocyte antigen) alert killer T cells by displaying bits of the virus on the surface of the cell. The T cells recognize these HIV fragments and mobilize an...

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2009-02-26 11:25:00

Development of an AIDS vaccine is becoming an even greater challenge as scientists reported on Thursday that the human immunodeficiency virus (HIV) is evolving at a fast pace in order to bypass the human body's immune system. Writing in the journal Nature, a worldwide team of scientists showed HIV was able to adapt rapidly to counter human genes controlling immune system molecules that can target it for destruction. HIV has killed 25 million people, and an estimated 33 million are currently...

2008-09-04 09:00:48

EDMONTON, Sept. 4 /PRNewswire-FirstCall/ -- BioMS Medical Corp. (TSX: MS), a leading developer in the treatment of multiple sclerosis (MS), today announced that the Food and Drug Administration (FDA) of the United States has granted fast track designation for the Company's lead drug, dirucotide (MBP8298), for the treatment of secondary progressive MS (SPMS). Dirucotide (MBP8298) is currently being evaluated in a U.S. pivotal phase III trial, named MAESTRO-03, at 68 sites with approximately...

2008-08-19 03:00:13

HLA-B*5701 biomarker indicates risk for severe adverse reactions to Abacavir / Experts expect more tests for similar markers in the future Venlo, The Netherlands - August 19, 2008 - QIAGEN (Nasdaq: QGEN; Frankfurt Prime Standard: QIA) today announced that it has introduced a new molecular diagnostic test to type the HLA-B*5701 allele, a genetic variation in the Human Leucocyte Antigen (HLA) system. HIV patients carrying the HLA-B*5701 marker have a 60% higher risk to develop...

2008-08-13 18:00:43

EDMONTON, Aug. 13 /PRNewswire-FirstCall/ -- BioMS Medical Corp. (TSX: MS), a leading developer in the treatment of multiple sclerosis (MS), today announced that the independent Drug Safety Monitoring Board (DSMB) for the MAESTRO-01 trial has conducted the scheduled interim analysis of efficacy and safety and has recommended that the trial continue to completion. MAESTRO-01 is the pivotal phase II/III Canadian and European study of dirucotide (MBP8298) in patients with secondary progressive...


Word of the Day
bellycheer
  • Good cheer; viands.
  • To revel; to feast.
The word 'bellycheer' may come from 'belle cheer', "good cheer".
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