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Latest Human mitochondrial genetics Stories

2010-10-28 12:38:00

--Studying the Cells' Power Plants, a Major Factor in Life Functions-- PHILADELPHIA, Oct. 28 /PRNewswire-USNewswire/ -- Douglas C. Wallace, Ph.D., a pioneer and internationally prominent scientist in the field of human mitochondrial genetics, has joined The Children's Hospital of Philadelphia to continue his investigations into the role of mitochondrial energy in health and disease. In establishing the Center of Mitochondrial and Epigenomic Medicine (CMEM) at Children's Hospital, Wallace...

2010-04-19 13:32:23

New research provides crucial insight into the pathogenic mechanisms of Parkinson's disease (PD), a prevalent neurodegenerative disorder. The study appears in the April 19 issue of the Journal of Cell Biology. The identification of inherited mutations in genes such as Parkin and PINK1 ( PTEN-induced putative kinase 1 ) has revealed key factors in the development of familial forms of the disease. Parkin adds ubiquitin molecules to other proteins to trigger their degradation, while PINK1...

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2010-04-16 08:22:16

Finds that cells without mitochondrial fusion have less mtDNA, more mutations in their mtDNA, and less ability to tolerate those mutations A typical human cell contains hundreds of mitochondria"”energy-producing organelles"”that continually fuse and divide. Relatively little is known, however, about why mitochondria undergo this behavior. In a paper published in the April 16 issue of the journal Cell, a team of researchers"”led by scientists at the California Institute of...

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2010-04-15 13:25:00

Embryos containing genetic material from a man and two women have been produced in a project that researchers are hailing as a "ray of hope" for thousands of families troubled by rare genetic diseases that can lead to heart failure, blindness, diabetes and even infant mortality. The technique used has researchers hopeful that it could be offered to women within three years. But the study is likely to re-spark the debate over the ethics of embryo research and "designer babies." Women who...

2009-10-23 12:08:40

Soon you could be genetically screened for mitochondrial disorders quickly and comprehensively. Research published in BioMed Central's open access journal, Genome Medicine, outlines an innovative clinical diagnostic test for the early identification of a wide range of mitochondrial disorders. Mutations to one of the mitochondrial genes, or to a number of nuclear genes with roles in mitochondrial function, can cause diseases which have very similar symptoms, making them difficult to diagnose...

2009-09-24 13:58:36

Researchers are delving into abnormal gene function in mitochondria, structures within cells that power our lives. Mitochondria are the place where energy is generated from the most basic molecules of food. Because this function is essential to life, defects in mitochondria may affect a wide range of organ systems in humans and animals. Some names of mitochondrial disorders are Leigh's disease, MELAS syndrome and complex I deficiency. These are often severe and progressive conditions that...

2009-09-24 11:00:00

PHILADELPHIA, Sept. 24 /PRNewswire-USNewswire/ -- Researchers are delving into abnormal gene function in mitochondria, structures within cells that power our lives. Mitochondria are the place where energy is generated from the most basic molecules of food. Because this function is essential to life, defects in mitochondria may affect a wide range of organ systems in humans and animals. Some names of mitochondrial disorders are Leigh's disease, MELAS syndrome and complex I deficiency....

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2009-08-27 06:20:00

Researchers believe they have found a way to avoid certain genetically inherited disorders through a special kind of in vitro fertilization (IVF).  Ethical concerns abound, but experts say that the future of the procedure looks promising. In lab experiments with rhesus macaque monkeys, scientists from the Oregon Health and Science University were recently able to transfer DNA from the nucleus of an unhealthy egg cell into a normal egg cell without a nucleus, ultimately resulting in the...

2009-08-06 10:35:57

The normal aging process has long been linked to problems with cell respiration, the process through which the cells extract energy from nutrients. Researchers at the Swedish medical university Karolinska Institutet have now shown how certain proteins that are synthesized in the cellular mitochondria "“ popularly known as the cells' power plants "“ become unstable and disintegrate, which in turn can impair cell respiration and cause premature aging.Every time we inhale, the blood...

2009-07-01 16:30:00

U.S. scientists studying how some human DNA mutations are involved in inherited diseases say their findings may affect the way genetic counseling is offered. Pennsylvania State University researchers said their study has shed light on the processes that lead to human DNA mutations implicated in such diseases as tuberous sclerosis and neurofibromatosis type 1. The scientists, led by Associate Professors Kateryna Makova and Francesca Chiaromonte, examined mutations in which small fragments of...


Word of the Day
bodacious
  • Remarkable; prodigious.
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This word is probably from the dialectal 'boldacious,' a blend of 'bold' and 'audacious.'
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