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Latest Huntingtin Stories

Huntington’s Disease May Lower Risk Of Cancer
2012-04-14 05:53:30

A Swedish study has shown that people with Huntington´s disease may have protection from cancer. The study also suggests there may be a genetic mechanism in diseases such as Huntington´s capable of fighting off cancer cells. Huntington´s is a debilitating brain condition and belongs to a group of illnesses known as polyglutamine (polyQ) diseases. These diseases are rare and all share a common genetic trait, which causes the repetition of certain genetic elements. This...

2011-12-23 06:48:49

(Ivanhoe Newswire) — Treatment that increases brain levels of a crucial regulatory enzyme may slow the loss of brain cells that characterize Huntington´s disease (HD) and other neurodegenerative disorders, according to this study. Increased expression of Sirt1, one of a family of enzymes called sirtuins, in the brain of a mouse model of HD protected against neurodegeneration. They also identified a potential mechanism for this protective effect. "Diseases such as Huntington's,...

2011-12-19 11:43:13

Mutant huntingtin protein appears to block activity of Sirt1, suggesting potential treatment target Treatment that increases brain levels of an important regulatory enzyme may slow the loss of brain cells that characterizes Huntington's disease (HD) and other neurodegenerative disorders. In a report receiving advance online publication in Nature Medicine, a Massachusetts General Hospital (MGH)-based research team reports that increased expression of Sirt1, one of a family of enzymes called...

2011-11-28 10:34:39

Huntington's disease (HD) is characterized by ongoing destruction of specific neurons within the brain. It affects a person's ability to walk, talk, and think - leading to involuntary movement and loss of muscle co-ordination. New research published in BioMed Central's open access journal Molecular Neurodegeneration shows that the RyanR inhibitor Dantrolene is able to reduce the severity of walking and balance problems in a mouse model of HD. Progressive damage to medium spiny neurons...

2011-11-15 19:23:37

Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is a universally fatal neurodegenerative disease. Mutations in two related proteins, TDP-43 and FUS, cause some forms of ALS. Specifically, these two proteins are RNA-binding proteins that connect to RNA to regulate the translation of proteins and other cellular functions such as RNA splicing and editing. In a new study, researchers at the Perelman School of Medicine at the University of Pennsylvania discovered additional human...

2011-10-31 10:16:28

Breakthrough discovery paves way for potential treatments Scientists at the Gladstone Institutes have discovered how a form of the protein linked to Huntington's disease influences the timing and severity of its symptoms, offering new avenues for treating not only this disease, but also a variety of similar conditions. In a paper being published today in Nature Chemical Biology, the laboratory of Gladstone Senior Investigator Steven Finkbeiner, MD, PhD, singles out one form of a...

2011-10-25 11:32:47

A tiny difference in the coding pattern of a single gene significantly affects the rate at which men's intellectual function drops with advancing age, investigators at the Stanford University School of Medicine and the Veterans Affairs Palo Alto Health Care System have learned. In a study to be published online Oct. 25 in Translational Psychiatry, the researchers tested the skills of experienced airplane pilots and found that having one version of the gene versus the other version doubled...

2011-10-12 11:30:23

Melatonin, best known for its role in sleep regulation, delayed the onset of symptoms and reduced mortality in a mouse model of Huntington's disease, say researchers at the University of Pittsburgh School of Medicine and Harvard Medical School. Their findings, published today in the Journal of Neuroscience, show for the first time that certain receptors for the hormone reside in the mitochondria, and that there are fewer of them both in affected mice and human brains. Huntington's disease...

2011-10-10 19:36:30

Huntington disease is a devastating neurogenerative disorder that causes a progressive loss of functional capacity and reduced life span. It is an inherited condition caused by a mutant HTT gene. Although this has been known for many years, the functions of the normal Htt protein and the mechanisms by which the mutant protein generated from the mutant HTT gene causes disease are not well understood. A team of researchers led by Frédéric Saudou, at the Institut Curie,...

2011-10-07 13:50:00

Ascent Scientific, together with Freie Universität Berlin, The University of Newcastle and Children's Medical Research Institute today announced that they have entered into an exclusive licence, supply and distribution agreement for the clathrin inhibitors Pitstop 1TM and Pitstop 2TM for research. These novel compounds are the first rationally designed inhibitors of clathrin, and represent important tools for investigating essential cellular processes such as endocytosis. The agreement...


Word of the Day
sough
  • A murmuring sound; a rushing or whistling sound, like that of the wind; a deep sigh.
  • A gentle breeze; a waft; a breath.
  • Any rumor that engages general attention.
  • A cant or whining mode of speaking, especially in preaching or praying; the chant or recitative characteristic of the old Presbyterians in Scotland.
  • To make a rushing, whistling, or sighing sound; emit a hollow murmur; murmur or sigh like the wind.
  • To breathe in or as in sleep.
  • To utter in a whining or monotonous tone.
According to the OED, from the 16th century, this word is 'almost exclusively Scots and northern dialect until adopted in general literary use in the 19th.'
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