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Last updated on April 20, 2014 at 8:28 EDT

Latest Huntingtin Stories

2011-08-11 07:00:00

CARLSBAD, Calif., Aug. 11, 2011 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) and CHDI Foundation, Inc. announced today a renewal of their collaboration to discover and develop an antisense drug for the treatment of Huntington's disease (HD), a fatal neurodegenerative disorder. This collaboration builds upon earlier successful alliances in which CHDI, a non-profit biomedical research organization dedicated to the development of therapeutics for HD, provided funding to support...

2011-07-18 15:42:53

A new study describes how hyperactivation of AMP-activated protein kinase (AMPK) promotes neurodegeneration in Huntington's disease (HD). The article appears online on July 18, 2011, in The Journal of Cell Biology (www.jcb.org). The aggregation of mutant Huntingtin protein in HD disrupts many cellular processes, including metabolism. AMPK"”a protein that balances a cell's energy production and usage"”is abnormally active in the brains of mice with HD, but whether the kinase...

2011-06-24 17:14:53

Johns Hopkins researchers identify a potential new way of blocking activity of gene that causes HD Johns Hopkins researchers have identified a natural mechanism that might one day be used to block the expression of the mutated gene known to cause Huntington's disease. Their experiments offer not an immediate cure, but a potential new approach to stopping or even preventing the development of this relentless neurodegenerative disorder. Huntington's disease is a rare, fatal disorder caused by a...

2011-06-21 18:34:17

A team of scientists, led by researchers at the University of California, San Diego School of Medicine, have uncovered a novel mechanism regulating gene expression and transcription linked to Spinocerebellar ataxia 7, an inherited neurological disorder. The discovery promises to have broad ramifications, suggesting that abundant non-coding transcripts of ribonucleic acid (RNA) may be key players in neurological development and function, and could be powerful targets for future clinical...

2011-05-31 15:04:47

McMaster University researchers have discovered a new drug target that may be effective at preventing the onset of Huntington's disease McMaster University researchers have discovered a new drug target that may be effective at preventing the onset of Huntington's disease, working much the same way heart medications slow the progression of heart disease and reduce heart attacks. Their landmark research discovered a family of kinase inhibitor drugs -- that all target one enzyme called IKK beta...

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2011-05-20 12:45:19

Researchers at the Department of Energy's Oak Ridge National Laboratory and the University of Tennessee have for the first time successfully characterized the earliest structural formation of the disease type of the protein that causes Huntington's disease. The incurable, hereditary neurological disorder is always fatal and affects one in 10,000 Americans.Huntington's disease is caused by a renegade protein "huntingtin" that destroys neurons in areas of the brain concerned with the emotions,...

2011-04-05 18:04:02

In Huntington's disease, the mutant protein known as huntingtin leads to the degeneration of a part of the brain known as the basal ganglia, causing the motor disturbances that represent one of the most defining features of the fatal disease. But a new study reported in the April issue of Cell Metabolism, a Cell Press publication, shows that the mutant protein also is responsible for metabolic imbalances in the hypothalamus, a brain region that plays an important role in appetite control....

2011-04-05 06:00:00

RICHMOND, Calif. and NEW YORK, April 5, 2011 /PRNewswire/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) and CHDI Foundation, Inc. have announced a collaboration to develop a novel therapeutic for Huntington's disease (HD) based on Sangamo's proprietary zinc finger DNA-binding protein (ZFP) technology. The ZFP therapeutic approach will target the huntingtin gene that causes HD, an inherited neurodegenerative disease for which there are currently no therapies available to slow disease...

2011-01-18 19:09:02

This molecule, a tiny strand of nucleotides called microRNA-29 or miR-29, has already been shown to be in short supply in certain neurodegenerative illnesses such as Alzheimer's disease and Huntington's disease. Thus, the discovery could herald a new treatment to prompt brain cells to survive in the wake of neurodegeneration or acute injury like stroke. Researchers at the University of North Carolina at Chapel Hill have discovered a molecule that can make brain cells resistant to programmed...

2011-01-05 22:59:55

Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS), and frontotemporal lobar degeneration (FTLD) are characterized by protein clumps in brain and spinal-cord cells that include an RNA-binding protein called TDP-43. This protein is the major building block of the lesions formed by these clumps. In a study published in the Journal of Clinical Investigation, a team led by Virginia M.-Y. Lee, PhD, director of Penn's Center for Neurodegenerative Disease Research, describes the first...