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Latest Huntington's disease clinical research Stories

2014-06-24 10:39:41

Washington University in St. Louis Researchers believe they have learned how mutations in the gene that causes Huntington’s disease kill brain cells, a finding that could open new opportunities for treating the fatal disorder. Scientists first linked the gene to the inherited disease more than 20 years ago. Huntington’s disease affects five to seven people out of every 100,000. Symptoms, which typically begin in middle age, include involuntary jerking movements, disrupted...

2013-11-27 13:19:32

A new study published 26th November in the open access journal PLOS Biology, identifies a new target in the search for therapeutic interventions for Huntington's disease – a devastating late-onset neurodegenerative disorder. The disease is genetic, affecting up to one person in 10,000, and from the age of about 35 leads to increasingly severe problems with movement, mental function, and behavior. Patients usually die within 20 years of onset, and there is to date no treatment that will...

For A Healthy Brain, Clear Out The Trash
2013-07-23 10:41:23

NIH/National Institute of Neurological Disorders and Stroke Recycling is not only good for the environment, it's good for the brain. A study using rat cells indicates that quickly clearing out defective proteins in the brain may prevent loss of brain cells. Results of a study in Nature Chemical Biology suggest that the speed at which damaged proteins are cleared from neurons may affect cell survival and may explain why some cells are targeted for death in neurodegenerative disorders....

2013-07-22 11:12:34

Gladstone-led study also finds target that boosts protein clearance, prolongs cell life Alzheimer's, Huntington's, Parkinson's. Names forever linked to what they represent: diseases that ravage the brain's neurons and leave entire regions to wither and die. These and other so-called neurodegenerative diseases are often associated with the buildup of toxic proteins that lead to the death of neurons. But now, scientists at the Gladstone Institutes have discovered that the progression of...

2012-09-17 23:11:46

A new light-based technique for measuring levels of the toxic protein that causes Huntington's disease (HD) has been used to demonstrate that the protein builds up gradually in blood cells. Published today (17th) in the Journal of Clinical Investigation, the findings shed light on how the protein causes damage in the brain, and could be useful for monitoring the progression of HD, or testing new drugs aimed at suppressing production of the harmful protein. HD is a fatal, incurable, genetic...

Skin Cells Create Stem Cells In Huntington Disease Study
2012-06-29 09:13:31

Connie K. Ho for redOrbit.com — Your Universe Online In 1993, the autosomal dominant gene mutation responsible for Huntington´s Disease (HD) was discovered. However, no treatments are known to slow its progression. New research may pave the way to better understanding of the disease. Researchers at Johns Hopkins recently announced that they were able to produce stem cells from skin cells from a person who had severe, early-onset form of HD; the cells were then changed into...

2012-06-29 06:15:57

(Ivanhoe Newswire) -- Using a human induced pluripotent stem cell (iPSC) from a patient suffering from Huntington´s disease, researchers at the Buck Institute for Research on Aging have corrected the genetic mutation that is responsible for the disease. To accomplish this process, researchers took the diseased iPSCs, made the genetic correction, generated neural stem cells, and then transplanted the mutation-free cells into a mouse model of Huntington´s disease where they are...

2012-06-21 06:19:46

(Ivanhoe Newswire) — More than 15,000 Americans have Huntington´s disease, a fatal condition marked by uncontrolled movements and cognitive and psychiatric problems. Currently, there are no available treatments to alter the effects of Huntington´s disease, but a new study brings researchers one step closer to finding one. A new gene-silencing strategy can reverse core symptoms associated with Huntington's disease, according to a preclinical study. The short-term therapy...

2012-06-21 02:19:04

A new gene-silencing strategy can reverse core symptoms associated with Huntington's disease, according to a preclinical study published by Cell Press in the June 21st issue of the journal Neuron. The short-term therapy produced sustained benefits in both mouse and primate animal models of this neurodegenerative disorder, which currently lacks an effective treatment. "Our approach is feasible for development now into a therapy for Huntington's disease in man," says senior study author Don...

2012-03-21 05:45:11

(Ivanhoe Newswire)-- Huntington's disease is a dreaded and debilitating congenital neurological disorder. There are little successful treatments and no cure. But a special type of brain cell forged from stem cells could help restore the muscle coordination deficits that cause the uncontrollable spasms characteristic of the disease. "This is really something unexpected," Su-Chun Zhang, a University of Wisconsin-Madison neuroscientist and the senior author of the new study, was quoted...


Word of the Day
sough
  • A murmuring sound; a rushing or whistling sound, like that of the wind; a deep sigh.
  • A gentle breeze; a waft; a breath.
  • Any rumor that engages general attention.
  • A cant or whining mode of speaking, especially in preaching or praying; the chant or recitative characteristic of the old Presbyterians in Scotland.
  • To make a rushing, whistling, or sighing sound; emit a hollow murmur; murmur or sigh like the wind.
  • To breathe in or as in sleep.
  • To utter in a whining or monotonous tone.
According to the OED, from the 16th century, this word is 'almost exclusively Scots and northern dialect until adopted in general literary use in the 19th.'
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